Cargando…
Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension
Background: Pulmonary hypertension (PH) is a well-established complication in interstitial lung disease (ILD) patients. The aim of this study is to investigate the physiological and hemodynamic parameters that predict mortality in patients with ILD-PH. Methods: Consecutive ILD patients who underwent...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760529/ https://www.ncbi.nlm.nih.gov/pubmed/33255999 http://dx.doi.org/10.3390/jcm9123828 |
_version_ | 1783627353953402880 |
---|---|
author | Alhamad, Esam H. Cal, Joseph G. Alrajhi, Nuha N. Alharbi, Waleed M. |
author_facet | Alhamad, Esam H. Cal, Joseph G. Alrajhi, Nuha N. Alharbi, Waleed M. |
author_sort | Alhamad, Esam H. |
collection | PubMed |
description | Background: Pulmonary hypertension (PH) is a well-established complication in interstitial lung disease (ILD) patients. The aim of this study is to investigate the physiological and hemodynamic parameters that predict mortality in patients with ILD-PH. Methods: Consecutive ILD patients who underwent right heart catheterization (n = 340) were included. The information analyzed included demographics and physiological and hemodynamic parameters. Cox regression models were used to identify independent predictors of survival. Results: In total, 96 patients had PH and an additional 56 patients had severe PH. The overall survival of idiopathic pulmonary fibrosis (IPF) patients with PH was significantly worse than the survival of patients with other types of ILD with PH (p < 0.0001 by log-rank analysis). Patients with a reduced diffusing capacity of the lung for carbon monoxide (DLco) (<35% predicted), six-minute walk test final oxygen saturation by pulse oximetry (SpO(2)) < 88% and pulmonary vascular resistance ≥4.5 Wood units in the ILD-PH cohort had significantly worse survival. IPF diagnosis, forced vital capacity, DLco, systolic pulmonary artery pressure and cardiac index were identified as independent predictors of survival among the ILD-PH cohort. Conclusions: Patients with ILD-PH have poor prognosis. Physiological and hemodynamic parameters were important factors independently associated with outcome. |
format | Online Article Text |
id | pubmed-7760529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77605292020-12-26 Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension Alhamad, Esam H. Cal, Joseph G. Alrajhi, Nuha N. Alharbi, Waleed M. J Clin Med Article Background: Pulmonary hypertension (PH) is a well-established complication in interstitial lung disease (ILD) patients. The aim of this study is to investigate the physiological and hemodynamic parameters that predict mortality in patients with ILD-PH. Methods: Consecutive ILD patients who underwent right heart catheterization (n = 340) were included. The information analyzed included demographics and physiological and hemodynamic parameters. Cox regression models were used to identify independent predictors of survival. Results: In total, 96 patients had PH and an additional 56 patients had severe PH. The overall survival of idiopathic pulmonary fibrosis (IPF) patients with PH was significantly worse than the survival of patients with other types of ILD with PH (p < 0.0001 by log-rank analysis). Patients with a reduced diffusing capacity of the lung for carbon monoxide (DLco) (<35% predicted), six-minute walk test final oxygen saturation by pulse oximetry (SpO(2)) < 88% and pulmonary vascular resistance ≥4.5 Wood units in the ILD-PH cohort had significantly worse survival. IPF diagnosis, forced vital capacity, DLco, systolic pulmonary artery pressure and cardiac index were identified as independent predictors of survival among the ILD-PH cohort. Conclusions: Patients with ILD-PH have poor prognosis. Physiological and hemodynamic parameters were important factors independently associated with outcome. MDPI 2020-11-26 /pmc/articles/PMC7760529/ /pubmed/33255999 http://dx.doi.org/10.3390/jcm9123828 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alhamad, Esam H. Cal, Joseph G. Alrajhi, Nuha N. Alharbi, Waleed M. Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title | Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title_full | Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title_fullStr | Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title_full_unstemmed | Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title_short | Predictors of Mortality in Patients with Interstitial Lung Disease-Associated Pulmonary Hypertension |
title_sort | predictors of mortality in patients with interstitial lung disease-associated pulmonary hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760529/ https://www.ncbi.nlm.nih.gov/pubmed/33255999 http://dx.doi.org/10.3390/jcm9123828 |
work_keys_str_mv | AT alhamadesamh predictorsofmortalityinpatientswithinterstitiallungdiseaseassociatedpulmonaryhypertension AT caljosephg predictorsofmortalityinpatientswithinterstitiallungdiseaseassociatedpulmonaryhypertension AT alrajhinuhan predictorsofmortalityinpatientswithinterstitiallungdiseaseassociatedpulmonaryhypertension AT alharbiwaleedm predictorsofmortalityinpatientswithinterstitiallungdiseaseassociatedpulmonaryhypertension |