Cargando…
Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall usin...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760562/ https://www.ncbi.nlm.nih.gov/pubmed/33260517 http://dx.doi.org/10.3390/ph13120434 |
_version_ | 1783627361713913856 |
---|---|
author | Cawthon, Claire V. Cooper, Kathryn Huett, Clifton Lloret, Alyssa Villar-Matamoros, Estefanny Stokes, Lauren Christians, Uwe Schuler, Michele Yazdani, Saami K. |
author_facet | Cawthon, Claire V. Cooper, Kathryn Huett, Clifton Lloret, Alyssa Villar-Matamoros, Estefanny Stokes, Lauren Christians, Uwe Schuler, Michele Yazdani, Saami K. |
author_sort | Cawthon, Claire V. |
collection | PubMed |
description | The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments. |
format | Online Article Text |
id | pubmed-7760562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77605622020-12-26 Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study Cawthon, Claire V. Cooper, Kathryn Huett, Clifton Lloret, Alyssa Villar-Matamoros, Estefanny Stokes, Lauren Christians, Uwe Schuler, Michele Yazdani, Saami K. Pharmaceuticals (Basel) Article The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments. MDPI 2020-11-28 /pmc/articles/PMC7760562/ /pubmed/33260517 http://dx.doi.org/10.3390/ph13120434 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cawthon, Claire V. Cooper, Kathryn Huett, Clifton Lloret, Alyssa Villar-Matamoros, Estefanny Stokes, Lauren Christians, Uwe Schuler, Michele Yazdani, Saami K. Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title | Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title_full | Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title_fullStr | Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title_full_unstemmed | Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title_short | Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study |
title_sort | pre-clinical investigation of liquid paclitaxel for local drug delivery: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760562/ https://www.ncbi.nlm.nih.gov/pubmed/33260517 http://dx.doi.org/10.3390/ph13120434 |
work_keys_str_mv | AT cawthonclairev preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT cooperkathryn preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT huettclifton preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT lloretalyssa preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT villarmatamorosestefanny preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT stokeslauren preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT christiansuwe preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT schulermichele preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy AT yazdanisaamik preclinicalinvestigationofliquidpaclitaxelforlocaldrugdeliveryapilotstudy |