Cargando…
Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer
The purpose was to investigate the interrater agreement of FDG-PET/CT and bone scintigraphy for diagnosing bone recurrence in breast cancer patients. A total of 100 women with suspected recurrence of breast cancer underwent planar whole-body bone scintigraphy with [99mTc]DPD and FDG-PET/CT. Scans we...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760596/ https://www.ncbi.nlm.nih.gov/pubmed/33260766 http://dx.doi.org/10.3390/diagnostics10121021 |
_version_ | 1783627369772220416 |
---|---|
author | Holm, Jorun Ahangarani Farahani, Ziba Gerke, Oke Baun, Christina Falch, Kirsten Malene Grubbe, Hildebrandt |
author_facet | Holm, Jorun Ahangarani Farahani, Ziba Gerke, Oke Baun, Christina Falch, Kirsten Malene Grubbe, Hildebrandt |
author_sort | Holm, Jorun |
collection | PubMed |
description | The purpose was to investigate the interrater agreement of FDG-PET/CT and bone scintigraphy for diagnosing bone recurrence in breast cancer patients. A total of 100 women with suspected recurrence of breast cancer underwent planar whole-body bone scintigraphy with [99mTc]DPD and FDG-PET/CT. Scans were evaluated independently by experienced nuclear medicine physicians and the results for one modality were blinded to the other. Images were visually interpreted using a 4-point assessment scale (0 = no metastases, 1 = probably no metastases, 2 = probably metastases, 3 = definite metastases). Out of 100 women, 22 (22%) were verified with distant recurrence, 18 of these had bone involvement. The proportions of agreement between readers were 93% (86.3–96.6) for bone recurrence with FDG-PET/CT and 47% (37.5–56.7) for bone recurrence with planar bone scintigraphy. The strengths of agreement between readers for diagnosing bone recurrence was ‘almost perfect’ with FDG-PET/CT and was ‘fair’ with planar bone scintigraphy according to Cohen’s kappa value of 0.82 (0.70–0.95) and 0.28 (0.18–0.39), respectively. Interrater agreement yielded improved reproducibility with FDG-PET/CT versus with bone scintigraphy when diagnosing recurrence with bone metastasis in this patient cohort. |
format | Online Article Text |
id | pubmed-7760596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77605962020-12-26 Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer Holm, Jorun Ahangarani Farahani, Ziba Gerke, Oke Baun, Christina Falch, Kirsten Malene Grubbe, Hildebrandt Diagnostics (Basel) Article The purpose was to investigate the interrater agreement of FDG-PET/CT and bone scintigraphy for diagnosing bone recurrence in breast cancer patients. A total of 100 women with suspected recurrence of breast cancer underwent planar whole-body bone scintigraphy with [99mTc]DPD and FDG-PET/CT. Scans were evaluated independently by experienced nuclear medicine physicians and the results for one modality were blinded to the other. Images were visually interpreted using a 4-point assessment scale (0 = no metastases, 1 = probably no metastases, 2 = probably metastases, 3 = definite metastases). Out of 100 women, 22 (22%) were verified with distant recurrence, 18 of these had bone involvement. The proportions of agreement between readers were 93% (86.3–96.6) for bone recurrence with FDG-PET/CT and 47% (37.5–56.7) for bone recurrence with planar bone scintigraphy. The strengths of agreement between readers for diagnosing bone recurrence was ‘almost perfect’ with FDG-PET/CT and was ‘fair’ with planar bone scintigraphy according to Cohen’s kappa value of 0.82 (0.70–0.95) and 0.28 (0.18–0.39), respectively. Interrater agreement yielded improved reproducibility with FDG-PET/CT versus with bone scintigraphy when diagnosing recurrence with bone metastasis in this patient cohort. MDPI 2020-11-28 /pmc/articles/PMC7760596/ /pubmed/33260766 http://dx.doi.org/10.3390/diagnostics10121021 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Holm, Jorun Ahangarani Farahani, Ziba Gerke, Oke Baun, Christina Falch, Kirsten Malene Grubbe, Hildebrandt Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title | Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title_full | Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title_fullStr | Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title_full_unstemmed | Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title_short | Higher Interrater Agreement of FDG-PET/CT than Bone Scintigraphy in Diagnosing Bone Recurrent Breast Cancer |
title_sort | higher interrater agreement of fdg-pet/ct than bone scintigraphy in diagnosing bone recurrent breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760596/ https://www.ncbi.nlm.nih.gov/pubmed/33260766 http://dx.doi.org/10.3390/diagnostics10121021 |
work_keys_str_mv | AT holmjorun higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer AT ahangaranifarahaniziba higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer AT gerkeoke higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer AT baunchristina higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer AT falchkirsten higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer AT malenegrubbehildebrandt higherinterrateragreementoffdgpetctthanbonescintigraphyindiagnosingbonerecurrentbreastcancer |