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Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders

Background: We evaluated the prevalence of psychiatric disorders in mild traumatic brain injury (MTBI) patients and investigated psychiatric comorbidity in relation to subjective symptoms and return to work (RTW). Methods: We recruited 103 MTBI patients (mean age 40.8 years, SD 3.1) prospectively fr...

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Autores principales: Marinkovic, Ivan, Isokuortti, Harri, Huovinen, Antti, Trpeska Marinkovic, Daniela, Mäki, Kaisa, Nybo, Taina, Korvenoja, Antti, Rahul, Raj, Vataja, Risto, Melkas, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760617/
https://www.ncbi.nlm.nih.gov/pubmed/33260933
http://dx.doi.org/10.3390/brainsci10120916
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author Marinkovic, Ivan
Isokuortti, Harri
Huovinen, Antti
Trpeska Marinkovic, Daniela
Mäki, Kaisa
Nybo, Taina
Korvenoja, Antti
Rahul, Raj
Vataja, Risto
Melkas, Susanna
author_facet Marinkovic, Ivan
Isokuortti, Harri
Huovinen, Antti
Trpeska Marinkovic, Daniela
Mäki, Kaisa
Nybo, Taina
Korvenoja, Antti
Rahul, Raj
Vataja, Risto
Melkas, Susanna
author_sort Marinkovic, Ivan
collection PubMed
description Background: We evaluated the prevalence of psychiatric disorders in mild traumatic brain injury (MTBI) patients and investigated psychiatric comorbidity in relation to subjective symptoms and return to work (RTW). Methods: We recruited 103 MTBI patients (mean age 40.8 years, SD 3.1) prospectively from University Hospital. The patients were followed up for one year. The Rivermead Post-Concussion Symptom Questionnaire (RPQ) and Extended Glasgow Outcome Scale (GOSE) were administered one month after MTBI. Three months after MTBI, any psychiatric disorders were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders. Results: Psychiatric disorders were diagnosed in 26 patients (25.2%). The most common disorders were previous/current depression. At three months, there was no difference between patients with psychiatric disorders versus those without them in RTW (95.7% vs. 87.3%, p = 0.260) or at least in part-time work (100% vs. 94.4%, p = 0.245). In Kaplan–Meier analysis, the median time to RTW was 10 days for both groups. The median RPQ score was 13.0 (Interquartile range (IQR) 6.5–19.0) in patients with a psychiatric disorder compared to 8.5 (IQR 2.3–14.0) in those without one (p = 0.021); respectively, the median GOSE was 7.0 (IQR 7.0–8.0) compared to 8.0 (IQR 7.0–8.0, p = 0.003). Conclusions: Approximately every fourth patient with MTBI had a psychiatric disorder. These patients reported more symptoms, and their functional outcome measured with GOSE at one month after MTBI was worse. However, presence of any psychiatric disorder did not affect RTW. Early contact and adequate follow-up are important when supporting the patient’s return to work.
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spelling pubmed-77606172020-12-26 Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders Marinkovic, Ivan Isokuortti, Harri Huovinen, Antti Trpeska Marinkovic, Daniela Mäki, Kaisa Nybo, Taina Korvenoja, Antti Rahul, Raj Vataja, Risto Melkas, Susanna Brain Sci Article Background: We evaluated the prevalence of psychiatric disorders in mild traumatic brain injury (MTBI) patients and investigated psychiatric comorbidity in relation to subjective symptoms and return to work (RTW). Methods: We recruited 103 MTBI patients (mean age 40.8 years, SD 3.1) prospectively from University Hospital. The patients were followed up for one year. The Rivermead Post-Concussion Symptom Questionnaire (RPQ) and Extended Glasgow Outcome Scale (GOSE) were administered one month after MTBI. Three months after MTBI, any psychiatric disorders were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders. Results: Psychiatric disorders were diagnosed in 26 patients (25.2%). The most common disorders were previous/current depression. At three months, there was no difference between patients with psychiatric disorders versus those without them in RTW (95.7% vs. 87.3%, p = 0.260) or at least in part-time work (100% vs. 94.4%, p = 0.245). In Kaplan–Meier analysis, the median time to RTW was 10 days for both groups. The median RPQ score was 13.0 (Interquartile range (IQR) 6.5–19.0) in patients with a psychiatric disorder compared to 8.5 (IQR 2.3–14.0) in those without one (p = 0.021); respectively, the median GOSE was 7.0 (IQR 7.0–8.0) compared to 8.0 (IQR 7.0–8.0, p = 0.003). Conclusions: Approximately every fourth patient with MTBI had a psychiatric disorder. These patients reported more symptoms, and their functional outcome measured with GOSE at one month after MTBI was worse. However, presence of any psychiatric disorder did not affect RTW. Early contact and adequate follow-up are important when supporting the patient’s return to work. MDPI 2020-11-27 /pmc/articles/PMC7760617/ /pubmed/33260933 http://dx.doi.org/10.3390/brainsci10120916 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marinkovic, Ivan
Isokuortti, Harri
Huovinen, Antti
Trpeska Marinkovic, Daniela
Mäki, Kaisa
Nybo, Taina
Korvenoja, Antti
Rahul, Raj
Vataja, Risto
Melkas, Susanna
Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title_full Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title_fullStr Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title_full_unstemmed Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title_short Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders
title_sort prognosis after mild traumatic brain injury: influence of psychiatric disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760617/
https://www.ncbi.nlm.nih.gov/pubmed/33260933
http://dx.doi.org/10.3390/brainsci10120916
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