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Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem

Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterin...

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Autores principales: Jabłoński, Krzysztof, Kurek, Łukasz, Żukowski, Maciej, Data-Jabłońska, Natalia, Żukowska, Karolina, Milewska, Anna J., Lipka, Aleksandra, Jóźwik, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760647/
https://www.ncbi.nlm.nih.gov/pubmed/33260709
http://dx.doi.org/10.3390/jcm9123870
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author Jabłoński, Krzysztof
Kurek, Łukasz
Żukowski, Maciej
Data-Jabłońska, Natalia
Żukowska, Karolina
Milewska, Anna J.
Lipka, Aleksandra
Jóźwik, Marcin
author_facet Jabłoński, Krzysztof
Kurek, Łukasz
Żukowski, Maciej
Data-Jabłońska, Natalia
Żukowska, Karolina
Milewska, Anna J.
Lipka, Aleksandra
Jóźwik, Marcin
author_sort Jabłoński, Krzysztof
collection PubMed
description Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium–endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (p < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening.
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spelling pubmed-77606472020-12-26 Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem Jabłoński, Krzysztof Kurek, Łukasz Żukowski, Maciej Data-Jabłońska, Natalia Żukowska, Karolina Milewska, Anna J. Lipka, Aleksandra Jóźwik, Marcin J Clin Med Article Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium–endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (p < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening. MDPI 2020-11-28 /pmc/articles/PMC7760647/ /pubmed/33260709 http://dx.doi.org/10.3390/jcm9123870 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jabłoński, Krzysztof
Kurek, Łukasz
Żukowski, Maciej
Data-Jabłońska, Natalia
Żukowska, Karolina
Milewska, Anna J.
Lipka, Aleksandra
Jóźwik, Marcin
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title_full Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title_fullStr Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title_full_unstemmed Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title_short Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
title_sort elastography of endometrium in women taking tamoxifen: a new approach to an old diagnostic problem
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760647/
https://www.ncbi.nlm.nih.gov/pubmed/33260709
http://dx.doi.org/10.3390/jcm9123870
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