Cargando…

Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles

Recent data have found that aging-related hearing loss (ARHL) is associated with the development of Alzheimer’s Disease (AD). However, the nature of the relationship between these two disorders is not clear. There are multiple potential factors that link ARHL and AD, and previous investigators have...

Descripción completa

Detalles Bibliográficos
Autores principales: Llano, Daniel A., Issa, Lina K., Devanarayan, Priya, Devanarayan, Viswanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760745/
https://www.ncbi.nlm.nih.gov/pubmed/33260532
http://dx.doi.org/10.3390/cells9122556
_version_ 1783627405732085760
author Llano, Daniel A.
Issa, Lina K.
Devanarayan, Priya
Devanarayan, Viswanath
author_facet Llano, Daniel A.
Issa, Lina K.
Devanarayan, Priya
Devanarayan, Viswanath
author_sort Llano, Daniel A.
collection PubMed
description Recent data have found that aging-related hearing loss (ARHL) is associated with the development of Alzheimer’s Disease (AD). However, the nature of the relationship between these two disorders is not clear. There are multiple potential factors that link ARHL and AD, and previous investigators have speculated that shared metabolic dysregulation may underlie the propensity to develop both disorders. Here, we investigate the distribution of serum lipidomic biomarkers in AD subjects with or without hearing loss in a publicly available dataset. Serum levels of 349 known lipids from 16 lipid classes were measured in 185 AD patients. Using previously defined co-regulated sets of lipids, both age- and sex-adjusted, we found that lipid sets enriched in phosphatidylcholine and phosphatidylethanolamine showed a strong inverse association with hearing loss. Examination of biochemical classes confirmed these relationships and revealed that serum phosphatidylcholine levels were significantly lower in AD subjects with hearing loss. A similar relationship was not found in normal subjects. These data suggest that a synergistic relationship may exist between AD, hearing loss and metabolic biomarkers, such that in the context of a pathological state such as AD, alterations in serum metabolic profiles are associated with hearing loss. These data also point to a potential role for phosphatidylcholine, a molecule with antioxidant properties, in the underlying pathophysiology of ARHL in the context of AD, which has implications for our understanding and potential treatment of both disorders.
format Online
Article
Text
id pubmed-7760745
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77607452020-12-26 Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles Llano, Daniel A. Issa, Lina K. Devanarayan, Priya Devanarayan, Viswanath Cells Article Recent data have found that aging-related hearing loss (ARHL) is associated with the development of Alzheimer’s Disease (AD). However, the nature of the relationship between these two disorders is not clear. There are multiple potential factors that link ARHL and AD, and previous investigators have speculated that shared metabolic dysregulation may underlie the propensity to develop both disorders. Here, we investigate the distribution of serum lipidomic biomarkers in AD subjects with or without hearing loss in a publicly available dataset. Serum levels of 349 known lipids from 16 lipid classes were measured in 185 AD patients. Using previously defined co-regulated sets of lipids, both age- and sex-adjusted, we found that lipid sets enriched in phosphatidylcholine and phosphatidylethanolamine showed a strong inverse association with hearing loss. Examination of biochemical classes confirmed these relationships and revealed that serum phosphatidylcholine levels were significantly lower in AD subjects with hearing loss. A similar relationship was not found in normal subjects. These data suggest that a synergistic relationship may exist between AD, hearing loss and metabolic biomarkers, such that in the context of a pathological state such as AD, alterations in serum metabolic profiles are associated with hearing loss. These data also point to a potential role for phosphatidylcholine, a molecule with antioxidant properties, in the underlying pathophysiology of ARHL in the context of AD, which has implications for our understanding and potential treatment of both disorders. MDPI 2020-11-28 /pmc/articles/PMC7760745/ /pubmed/33260532 http://dx.doi.org/10.3390/cells9122556 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Llano, Daniel A.
Issa, Lina K.
Devanarayan, Priya
Devanarayan, Viswanath
Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title_full Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title_fullStr Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title_full_unstemmed Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title_short Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles
title_sort hearing loss in alzheimer’s disease is associated with altered serum lipidomic biomarker profiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760745/
https://www.ncbi.nlm.nih.gov/pubmed/33260532
http://dx.doi.org/10.3390/cells9122556
work_keys_str_mv AT llanodaniela hearinglossinalzheimersdiseaseisassociatedwithalteredserumlipidomicbiomarkerprofiles
AT issalinak hearinglossinalzheimersdiseaseisassociatedwithalteredserumlipidomicbiomarkerprofiles
AT devanarayanpriya hearinglossinalzheimersdiseaseisassociatedwithalteredserumlipidomicbiomarkerprofiles
AT devanarayanviswanath hearinglossinalzheimersdiseaseisassociatedwithalteredserumlipidomicbiomarkerprofiles
AT hearinglossinalzheimersdiseaseisassociatedwithalteredserumlipidomicbiomarkerprofiles