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Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age

Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of...

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Autores principales: Kyriakidou, Maria, Chatziioannidis, Ilias, Mitsiakos, Georgios, Lampropoulou, Sofia, Pouliakis, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760848/
https://www.ncbi.nlm.nih.gov/pubmed/33256108
http://dx.doi.org/10.3390/medicina56120649
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author Kyriakidou, Maria
Chatziioannidis, Ilias
Mitsiakos, Georgios
Lampropoulou, Sofia
Pouliakis, Abraham
author_facet Kyriakidou, Maria
Chatziioannidis, Ilias
Mitsiakos, Georgios
Lampropoulou, Sofia
Pouliakis, Abraham
author_sort Kyriakidou, Maria
collection PubMed
description Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley–III neurodevelopmental assessment at 2–3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes.
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spelling pubmed-77608482020-12-26 Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age Kyriakidou, Maria Chatziioannidis, Ilias Mitsiakos, Georgios Lampropoulou, Sofia Pouliakis, Abraham Medicina (Kaunas) Article Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley–III neurodevelopmental assessment at 2–3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes. MDPI 2020-11-26 /pmc/articles/PMC7760848/ /pubmed/33256108 http://dx.doi.org/10.3390/medicina56120649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kyriakidou, Maria
Chatziioannidis, Ilias
Mitsiakos, Georgios
Lampropoulou, Sofia
Pouliakis, Abraham
Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title_full Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title_fullStr Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title_full_unstemmed Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title_short Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
title_sort neurodevelopmental outcome in extremely low birth weight infants at 2–3 years of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760848/
https://www.ncbi.nlm.nih.gov/pubmed/33256108
http://dx.doi.org/10.3390/medicina56120649
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