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Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age
Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760848/ https://www.ncbi.nlm.nih.gov/pubmed/33256108 http://dx.doi.org/10.3390/medicina56120649 |
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author | Kyriakidou, Maria Chatziioannidis, Ilias Mitsiakos, Georgios Lampropoulou, Sofia Pouliakis, Abraham |
author_facet | Kyriakidou, Maria Chatziioannidis, Ilias Mitsiakos, Georgios Lampropoulou, Sofia Pouliakis, Abraham |
author_sort | Kyriakidou, Maria |
collection | PubMed |
description | Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley–III neurodevelopmental assessment at 2–3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes. |
format | Online Article Text |
id | pubmed-7760848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77608482020-12-26 Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age Kyriakidou, Maria Chatziioannidis, Ilias Mitsiakos, Georgios Lampropoulou, Sofia Pouliakis, Abraham Medicina (Kaunas) Article Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley–III neurodevelopmental assessment at 2–3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes. MDPI 2020-11-26 /pmc/articles/PMC7760848/ /pubmed/33256108 http://dx.doi.org/10.3390/medicina56120649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kyriakidou, Maria Chatziioannidis, Ilias Mitsiakos, Georgios Lampropoulou, Sofia Pouliakis, Abraham Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title | Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title_full | Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title_fullStr | Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title_full_unstemmed | Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title_short | Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age |
title_sort | neurodevelopmental outcome in extremely low birth weight infants at 2–3 years of age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760848/ https://www.ncbi.nlm.nih.gov/pubmed/33256108 http://dx.doi.org/10.3390/medicina56120649 |
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