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Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer

With the development of systemic treatments with high response rates, including tyrosine kinase inhibitors and immune checkpoint inhibitors, some patients with unresectable lung cancer now have a chance to undergo radical resection after primary treatment. Although there is no general consensus rega...

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Detalles Bibliográficos
Autores principales: Suzuki, Shigeki, Goto, Taichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760873/
https://www.ncbi.nlm.nih.gov/pubmed/33260352
http://dx.doi.org/10.3390/jcm9123881
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author Suzuki, Shigeki
Goto, Taichiro
author_facet Suzuki, Shigeki
Goto, Taichiro
author_sort Suzuki, Shigeki
collection PubMed
description With the development of systemic treatments with high response rates, including tyrosine kinase inhibitors and immune checkpoint inhibitors, some patients with unresectable lung cancer now have a chance to undergo radical resection after primary treatment. Although there is no general consensus regarding the definition of “unresectable” in lung cancer, the term “resectable” refers to technically resectable and indicates that resection can provide a favorable prognosis to some extent. Unresectable lung cancer is typically represented by stage III and IV disease. Stage III lung cancer is a heterogeneous disease, and in some patients with technically resectable non-small cell lung cancer (NSCLC), multimodality treatments, including induction chemoradiotherapy followed by surgery, are the treatments of choice. The representative surgical intervention for unresectable stage III/IV NSCLC is salvage surgery, which refers to surgical treatment for local residual/recurrent lesions after definitive non-surgical treatment. Surgical intervention is also used for an oligometastatic stage IV NSCLC. In this review, we highlight the role of surgical intervention in patients with unresectable NSCLC, for whom an initial complete resection is technically difficult. We further describe the history of and new findings on salvage surgery for unresectable NSCLC and surgery for oligometastatic NSCLC.
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spelling pubmed-77608732020-12-26 Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer Suzuki, Shigeki Goto, Taichiro J Clin Med Review With the development of systemic treatments with high response rates, including tyrosine kinase inhibitors and immune checkpoint inhibitors, some patients with unresectable lung cancer now have a chance to undergo radical resection after primary treatment. Although there is no general consensus regarding the definition of “unresectable” in lung cancer, the term “resectable” refers to technically resectable and indicates that resection can provide a favorable prognosis to some extent. Unresectable lung cancer is typically represented by stage III and IV disease. Stage III lung cancer is a heterogeneous disease, and in some patients with technically resectable non-small cell lung cancer (NSCLC), multimodality treatments, including induction chemoradiotherapy followed by surgery, are the treatments of choice. The representative surgical intervention for unresectable stage III/IV NSCLC is salvage surgery, which refers to surgical treatment for local residual/recurrent lesions after definitive non-surgical treatment. Surgical intervention is also used for an oligometastatic stage IV NSCLC. In this review, we highlight the role of surgical intervention in patients with unresectable NSCLC, for whom an initial complete resection is technically difficult. We further describe the history of and new findings on salvage surgery for unresectable NSCLC and surgery for oligometastatic NSCLC. MDPI 2020-11-29 /pmc/articles/PMC7760873/ /pubmed/33260352 http://dx.doi.org/10.3390/jcm9123881 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suzuki, Shigeki
Goto, Taichiro
Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title_full Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title_fullStr Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title_full_unstemmed Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title_short Role of Surgical Intervention in Unresectable Non-Small Cell Lung Cancer
title_sort role of surgical intervention in unresectable non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760873/
https://www.ncbi.nlm.nih.gov/pubmed/33260352
http://dx.doi.org/10.3390/jcm9123881
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