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Current Nanoparticle-Based Technologies for Osteoarthritis Therapy
Osteoarthritis (OA) is a common chronic joint disease that is characterized by joint pain and stiffness, and limitation of motion and the major cause of disability, which reduces life quality of patients and brings a large economic burden to the family and society. Current clinical treatment is most...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760945/ https://www.ncbi.nlm.nih.gov/pubmed/33260493 http://dx.doi.org/10.3390/nano10122368 |
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author | Jin, Guang-Zhen |
author_facet | Jin, Guang-Zhen |
author_sort | Jin, Guang-Zhen |
collection | PubMed |
description | Osteoarthritis (OA) is a common chronic joint disease that is characterized by joint pain and stiffness, and limitation of motion and the major cause of disability, which reduces life quality of patients and brings a large economic burden to the family and society. Current clinical treatment is mostly limited to symptomatic treatment aimed at pain alleviation and functional improvement, rather than suppressing the progression of OA. Nanotechnology is a promising strategy for the treatment of OA. In this review, we summarize the current experimental progress that focuses on technologies such as liposomes, micelles, dendrimers, polymeric nanoparticles (PNPs), exosomes, and inorganic nanoparticles (NPs) for their potential treatment of OA. |
format | Online Article Text |
id | pubmed-7760945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77609452020-12-26 Current Nanoparticle-Based Technologies for Osteoarthritis Therapy Jin, Guang-Zhen Nanomaterials (Basel) Review Osteoarthritis (OA) is a common chronic joint disease that is characterized by joint pain and stiffness, and limitation of motion and the major cause of disability, which reduces life quality of patients and brings a large economic burden to the family and society. Current clinical treatment is mostly limited to symptomatic treatment aimed at pain alleviation and functional improvement, rather than suppressing the progression of OA. Nanotechnology is a promising strategy for the treatment of OA. In this review, we summarize the current experimental progress that focuses on technologies such as liposomes, micelles, dendrimers, polymeric nanoparticles (PNPs), exosomes, and inorganic nanoparticles (NPs) for their potential treatment of OA. MDPI 2020-11-28 /pmc/articles/PMC7760945/ /pubmed/33260493 http://dx.doi.org/10.3390/nano10122368 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jin, Guang-Zhen Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title | Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title_full | Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title_fullStr | Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title_full_unstemmed | Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title_short | Current Nanoparticle-Based Technologies for Osteoarthritis Therapy |
title_sort | current nanoparticle-based technologies for osteoarthritis therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760945/ https://www.ncbi.nlm.nih.gov/pubmed/33260493 http://dx.doi.org/10.3390/nano10122368 |
work_keys_str_mv | AT jinguangzhen currentnanoparticlebasedtechnologiesforosteoarthritistherapy |