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Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy

Nanofluidic devices have offered us fascinating analytical platforms for chemical and bioanalysis by exploiting unique properties of liquids and molecules confined in nanospaces. The increasing interests in nanofluidic analytical devices have triggered the development of new robust and sensitive det...

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Autores principales: Le, Thu Hac Huong, Matsushita, Takumi, Ohta, Ryoichi, Shimoda, Yuta, Matsui, Hiroaki, Kitamori, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760999/
https://www.ncbi.nlm.nih.gov/pubmed/33266007
http://dx.doi.org/10.3390/mi11121062
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author Le, Thu Hac Huong
Matsushita, Takumi
Ohta, Ryoichi
Shimoda, Yuta
Matsui, Hiroaki
Kitamori, Takehiko
author_facet Le, Thu Hac Huong
Matsushita, Takumi
Ohta, Ryoichi
Shimoda, Yuta
Matsui, Hiroaki
Kitamori, Takehiko
author_sort Le, Thu Hac Huong
collection PubMed
description Nanofluidic devices have offered us fascinating analytical platforms for chemical and bioanalysis by exploiting unique properties of liquids and molecules confined in nanospaces. The increasing interests in nanofluidic analytical devices have triggered the development of new robust and sensitive detection techniques, especially label-free ones. IR absorption spectroscopy is one of the most powerful biochemical analysis methods for identification and quantitative measurement of chemical species in the label-free and non-invasive fashion. However, the low sensitivity and the difficulties in fabrication of IR-compatible nanofluidic devices are major obstacles that restrict the applications of IR spectroscopy in nanofluidics. Here, we realized the bonding of CaF(2) and SiO(2) at room temperature and demonstrated an IR-compatible nanofluidic device that allowed the IR spectroscopy in a wide range of mid-IR regime. We also performed the integration of metal-insulator-metal perfect absorber metamaterials into nanofluidic devices for plasmon-enhanced infrared absorption spectroscopy with ultrahigh sensitivity. This study also shows a proof-of-concept of the multi-band absorber by combining different types of nanostructures. The results indicate the potential of implementing metamaterials in tracking several characteristic molecular vibrational modes simultaneously, making it possible to identify molecular species in mixture or complex biological entities.
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spelling pubmed-77609992020-12-26 Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy Le, Thu Hac Huong Matsushita, Takumi Ohta, Ryoichi Shimoda, Yuta Matsui, Hiroaki Kitamori, Takehiko Micromachines (Basel) Article Nanofluidic devices have offered us fascinating analytical platforms for chemical and bioanalysis by exploiting unique properties of liquids and molecules confined in nanospaces. The increasing interests in nanofluidic analytical devices have triggered the development of new robust and sensitive detection techniques, especially label-free ones. IR absorption spectroscopy is one of the most powerful biochemical analysis methods for identification and quantitative measurement of chemical species in the label-free and non-invasive fashion. However, the low sensitivity and the difficulties in fabrication of IR-compatible nanofluidic devices are major obstacles that restrict the applications of IR spectroscopy in nanofluidics. Here, we realized the bonding of CaF(2) and SiO(2) at room temperature and demonstrated an IR-compatible nanofluidic device that allowed the IR spectroscopy in a wide range of mid-IR regime. We also performed the integration of metal-insulator-metal perfect absorber metamaterials into nanofluidic devices for plasmon-enhanced infrared absorption spectroscopy with ultrahigh sensitivity. This study also shows a proof-of-concept of the multi-band absorber by combining different types of nanostructures. The results indicate the potential of implementing metamaterials in tracking several characteristic molecular vibrational modes simultaneously, making it possible to identify molecular species in mixture or complex biological entities. MDPI 2020-11-30 /pmc/articles/PMC7760999/ /pubmed/33266007 http://dx.doi.org/10.3390/mi11121062 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Le, Thu Hac Huong
Matsushita, Takumi
Ohta, Ryoichi
Shimoda, Yuta
Matsui, Hiroaki
Kitamori, Takehiko
Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title_full Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title_fullStr Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title_full_unstemmed Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title_short Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy
title_sort fabrication of infrared-compatible nanofluidic devices for plasmon-enhanced infrared absorption spectroscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760999/
https://www.ncbi.nlm.nih.gov/pubmed/33266007
http://dx.doi.org/10.3390/mi11121062
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