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Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development

The COVID-19 pandemic is responsible for an unprecedented disruption to the healthcare systems and economies of countries around the world. Developing novel therapeutics and a vaccine against SARS-CoV-2 requires an understanding of the similarities and differences between the various human coronavir...

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Autores principales: Oves, Mohammad, Ravindran, Mithunan, Rauf, Mohd Ahmar, Omaish Ansari, Mohammad, Zahin, Maryam, Iyer, Arun K., Ismail, Iqbal M. I., Khan, Meraj A., Palaniyar, Nades
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761006/
https://www.ncbi.nlm.nih.gov/pubmed/33255989
http://dx.doi.org/10.3390/pathogens9120985
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author Oves, Mohammad
Ravindran, Mithunan
Rauf, Mohd Ahmar
Omaish Ansari, Mohammad
Zahin, Maryam
Iyer, Arun K.
Ismail, Iqbal M. I.
Khan, Meraj A.
Palaniyar, Nades
author_facet Oves, Mohammad
Ravindran, Mithunan
Rauf, Mohd Ahmar
Omaish Ansari, Mohammad
Zahin, Maryam
Iyer, Arun K.
Ismail, Iqbal M. I.
Khan, Meraj A.
Palaniyar, Nades
author_sort Oves, Mohammad
collection PubMed
description The COVID-19 pandemic is responsible for an unprecedented disruption to the healthcare systems and economies of countries around the world. Developing novel therapeutics and a vaccine against SARS-CoV-2 requires an understanding of the similarities and differences between the various human coronaviruses with regards to their phylogenic relationships, transmission, and management. Phylogenetic analysis indicates that humans were first infected with SARS-CoV-2 in late 2019 and the virus rapidly spread from the outbreak epicenter in Wuhan, China to various parts of the world. Multiple variants of SARS-CoV-2 have now been identified in particular regions. It is apparent that MERS, SARS-CoV, and SARS-CoV-2 present with several common symptoms including fever, cough, and dyspnea in mild cases, but can also progress to pneumonia and acute respiratory distress syndrome. Understanding the molecular steps leading to SARS-CoV-2 entry into cells and the viral replication cycle can illuminate crucial targets for testing several potential therapeutics. Genomic and structural details of SARS-CoV-2 and previous attempts to generate vaccines against SARS-CoV and MERS have provided vaccine targets to manage future outbreaks more effectively. The coordinated global response against this emerging infectious disease is unique and has helped address the need for urgent therapeutics and vaccines in a remarkably short time.
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spelling pubmed-77610062020-12-26 Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development Oves, Mohammad Ravindran, Mithunan Rauf, Mohd Ahmar Omaish Ansari, Mohammad Zahin, Maryam Iyer, Arun K. Ismail, Iqbal M. I. Khan, Meraj A. Palaniyar, Nades Pathogens Review The COVID-19 pandemic is responsible for an unprecedented disruption to the healthcare systems and economies of countries around the world. Developing novel therapeutics and a vaccine against SARS-CoV-2 requires an understanding of the similarities and differences between the various human coronaviruses with regards to their phylogenic relationships, transmission, and management. Phylogenetic analysis indicates that humans were first infected with SARS-CoV-2 in late 2019 and the virus rapidly spread from the outbreak epicenter in Wuhan, China to various parts of the world. Multiple variants of SARS-CoV-2 have now been identified in particular regions. It is apparent that MERS, SARS-CoV, and SARS-CoV-2 present with several common symptoms including fever, cough, and dyspnea in mild cases, but can also progress to pneumonia and acute respiratory distress syndrome. Understanding the molecular steps leading to SARS-CoV-2 entry into cells and the viral replication cycle can illuminate crucial targets for testing several potential therapeutics. Genomic and structural details of SARS-CoV-2 and previous attempts to generate vaccines against SARS-CoV and MERS have provided vaccine targets to manage future outbreaks more effectively. The coordinated global response against this emerging infectious disease is unique and has helped address the need for urgent therapeutics and vaccines in a remarkably short time. MDPI 2020-11-26 /pmc/articles/PMC7761006/ /pubmed/33255989 http://dx.doi.org/10.3390/pathogens9120985 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oves, Mohammad
Ravindran, Mithunan
Rauf, Mohd Ahmar
Omaish Ansari, Mohammad
Zahin, Maryam
Iyer, Arun K.
Ismail, Iqbal M. I.
Khan, Meraj A.
Palaniyar, Nades
Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title_full Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title_fullStr Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title_full_unstemmed Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title_short Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development
title_sort comparing and contrasting mers, sars-cov, and sars-cov-2: prevention, transmission, management, and vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761006/
https://www.ncbi.nlm.nih.gov/pubmed/33255989
http://dx.doi.org/10.3390/pathogens9120985
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