Cargando…

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells

Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insuf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Welter, Harald, Herrmann, Carola, Fröhlich, Thomas, Flenkenthaler, Florian, Eubler, Katja, Schorle, Hubert, Nettersheim, Daniel, Mayerhofer, Artur, Müller-Taubenberger, Annette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761120/ https://www.ncbi.nlm.nih.gov/pubmed/33266100 http://dx.doi.org/10.3390/cells9122563

Ejemplares similares

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo
por: Nettersheim, Daniel, et al.
Publicado: (2019)

SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate
por: Nettersheim, Daniel, et al.
Publicado: (2016)

Cytoskeleton Modifications and Autophagy Induction in TCam-2 Seminoma Cells Exposed to Simulated Microgravity
por: Ferranti, Francesca, et al.
Publicado: (2014)

Testis developmental related gene 1 regulates the chemosensitivity of seminoma TCam‐2 cells to cisplatin via autophagy
por: Peng, Dongyi, et al.
Publicado: (2019)

The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas
por: Nettersheim, Daniel, et al.
Publicado: (2016)

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro
por: Fink, Cornelia, et al.
Publicado: (2021)

A Coculture Model Mimicking the Tumor Microenvironment Unveils Mutual Interactions between Immune Cell Subtypes and the Human Seminoma Cell Line TCam-2
por: Gayer, Fabian A., et al.
Publicado: (2022)

The plasticity of germ cell cancers and its dependence on the cellular microenvironment
por: Nettersheim, Daniel, et al.
Publicado: (2017)

Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2
por: Eubler, Katja, et al.
Publicado: (2018)

TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis
por: Ferranti, Francesca, et al.
Publicado: (2013)

The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype
por: Welter, Harald, et al.
Publicado: (2020)

Correction: TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis
por: Ferranti, Francesca, et al.
Publicado: (2013)

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma
por: Nettersheim, Daniel, et al.
Publicado: (2015)

The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis
por: Liebich, Annika, et al.
Publicado: (2022)

Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies
por: Schulz, Birte, et al.
Publicado: (2023)

Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin
Publicado: (1983)

Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors
por: Nettersheim, Daniel, et al.
Publicado: (2018)

Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model
por: Stöckl, Jan B., et al.
Publicado: (2020)

Spectraplakins: Master orchestrators of cytoskeletal dynamics
por: Suozzi, Kathleen C., et al.
Publicado: (2012)

A Role for H(2)O(2) and TRPM2 in the Induction of Cell Death: Studies in KGN Cells
por: Hack, Carsten Theo, et al.
Publicado: (2019)

A rapid and robust method for the cryopreservation of human granulosa cells
por: Beschta, Sarah, et al.
Publicado: (2021)

Profound Effects of Dexamethasone on the Immunological State, Synthesis and Secretion Capacity of Human Testicular Peritubular Cells
por: Stepanov, Youli Konstantinovitch, et al.
Publicado: (2022)

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity
por: Morabito, C., et al.
Publicado: (2017)

Simulated Microgravity Exposure Induces Antioxidant Barrier Deregulation and Mitochondria Enlargement in TCam-2 Cell Spheroids
por: Berardini, Marika, et al.
Publicado: (2023)

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment
por: Nettersheim, Daniel, et al.
Publicado: (2016)

Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis
por: Eubler, Katja, et al.
Publicado: (2021)

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
por: Eckert, Dawid, et al.
Publicado: (2008)

Filamins Regulate Cell Spreading and Initiation of Cell Migration
por: Baldassarre, Massimiliano, et al.
Publicado: (2009)

Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism
por: Li Fraine, Steven, et al.
Publicado: (2017)

Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours
por: Funke, Kai, et al.
Publicado: (2023)

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate
por: Stöckl, Jan B., et al.
Publicado: (2021)

Insights into replicative senescence of human testicular peritubular cells
por: Schmid, Nina, et al.
Publicado: (2019)

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines
por: Schönberger, Stefan, et al.
Publicado: (2020)

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
por: Junqueira Alves, Chrystian, et al.
Publicado: (2021)

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules
por: Windschüttl, S., et al.
Publicado: (2015)

Biological roles of filamin a in prostate cancer cells
por: Li, Xue-Chao, et al.
Publicado: (2019)

Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model
por: Smialek, Maciej J., et al.
Publicado: (2020)

Traditional complementary and alternative medicine (TCAM) for diabetic foot ulcer management: A systematic review
por: Kumar, Suman, et al.
Publicado: (2023)

Brentuximab vedotin exerts profound antiproliferative and pro‐apoptotic efficacy in CD30‐positive as well as cocultured CD30‐negative germ cell tumour cell lines
por: Schönberger, Stefan, et al.
Publicado: (2017)

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo
por: Jostes, Sina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_d5orpphu97ak36eu76h36muovi