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Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study
Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus inte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761125/ https://www.ncbi.nlm.nih.gov/pubmed/33255481 http://dx.doi.org/10.3390/brainsci10120905 |
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author | Malejko, Kathrin Huss, André Schönfeldt-Lecuona, Carlos Braun, Maren Graf, Heiko |
author_facet | Malejko, Kathrin Huss, André Schönfeldt-Lecuona, Carlos Braun, Maren Graf, Heiko |
author_sort | Malejko, Kathrin |
collection | PubMed |
description | Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels. |
format | Online Article Text |
id | pubmed-7761125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77611252020-12-26 Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study Malejko, Kathrin Huss, André Schönfeldt-Lecuona, Carlos Braun, Maren Graf, Heiko Brain Sci Article Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels. MDPI 2020-11-24 /pmc/articles/PMC7761125/ /pubmed/33255481 http://dx.doi.org/10.3390/brainsci10120905 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Malejko, Kathrin Huss, André Schönfeldt-Lecuona, Carlos Braun, Maren Graf, Heiko Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title | Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title_full | Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title_fullStr | Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title_full_unstemmed | Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title_short | Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study |
title_sort | emotional components of pain perception in borderline personality disorder and major depression—a repetitive peripheral magnetic stimulation (rpms) study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761125/ https://www.ncbi.nlm.nih.gov/pubmed/33255481 http://dx.doi.org/10.3390/brainsci10120905 |
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