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Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections

Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefor...

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Autores principales: Ghosh, Pria N., Brookes, Lola M., Edwards, Hannah M., Fisher, Matthew C., Jervis, Phillip, Kappel, Dana, Sewell, Thomas R., Shelton, Jennifer M.G., Skelly, Emily, Rhodes, Johanna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761180/
https://www.ncbi.nlm.nih.gov/pubmed/33260763
http://dx.doi.org/10.3390/life10120315
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author Ghosh, Pria N.
Brookes, Lola M.
Edwards, Hannah M.
Fisher, Matthew C.
Jervis, Phillip
Kappel, Dana
Sewell, Thomas R.
Shelton, Jennifer M.G.
Skelly, Emily
Rhodes, Johanna L.
author_facet Ghosh, Pria N.
Brookes, Lola M.
Edwards, Hannah M.
Fisher, Matthew C.
Jervis, Phillip
Kappel, Dana
Sewell, Thomas R.
Shelton, Jennifer M.G.
Skelly, Emily
Rhodes, Johanna L.
author_sort Ghosh, Pria N.
collection PubMed
description Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future.
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spelling pubmed-77611802020-12-26 Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections Ghosh, Pria N. Brookes, Lola M. Edwards, Hannah M. Fisher, Matthew C. Jervis, Phillip Kappel, Dana Sewell, Thomas R. Shelton, Jennifer M.G. Skelly, Emily Rhodes, Johanna L. Life (Basel) Review Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future. MDPI 2020-11-28 /pmc/articles/PMC7761180/ /pubmed/33260763 http://dx.doi.org/10.3390/life10120315 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghosh, Pria N.
Brookes, Lola M.
Edwards, Hannah M.
Fisher, Matthew C.
Jervis, Phillip
Kappel, Dana
Sewell, Thomas R.
Shelton, Jennifer M.G.
Skelly, Emily
Rhodes, Johanna L.
Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title_full Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title_fullStr Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title_full_unstemmed Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title_short Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
title_sort cross-disciplinary genomics approaches to studying emerging fungal infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761180/
https://www.ncbi.nlm.nih.gov/pubmed/33260763
http://dx.doi.org/10.3390/life10120315
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