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Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis

Background: Sarcoidosis is one of the leading causes of uveitis. To date, no studies have assessed the factors specifically related with recovery in ocular sarcoidosis. In this study, we aimed to determine factors associated with ocular and extraocular recovery in patients with sarcoid uveitis. Meth...

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Autores principales: Bienvenu, Francois-Henri, Tiffet, Théophile, Maucort-Boulch, Delphine, Gerfaud-Valentin, Mathieu, Kodjikian, Laurent, Perard, Laurent, Burillon, Carole, Durel, Cécile-Audrey, Hot, Arnaud, Jamilloux, Yvan, Seve, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761190/
https://www.ncbi.nlm.nih.gov/pubmed/33266254
http://dx.doi.org/10.3390/jcm9123894
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author Bienvenu, Francois-Henri
Tiffet, Théophile
Maucort-Boulch, Delphine
Gerfaud-Valentin, Mathieu
Kodjikian, Laurent
Perard, Laurent
Burillon, Carole
Durel, Cécile-Audrey
Hot, Arnaud
Jamilloux, Yvan
Seve, Pascal
author_facet Bienvenu, Francois-Henri
Tiffet, Théophile
Maucort-Boulch, Delphine
Gerfaud-Valentin, Mathieu
Kodjikian, Laurent
Perard, Laurent
Burillon, Carole
Durel, Cécile-Audrey
Hot, Arnaud
Jamilloux, Yvan
Seve, Pascal
author_sort Bienvenu, Francois-Henri
collection PubMed
description Background: Sarcoidosis is one of the leading causes of uveitis. To date, no studies have assessed the factors specifically related with recovery in ocular sarcoidosis. In this study, we aimed to determine factors associated with ocular and extraocular recovery in patients with sarcoid uveitis. Methods: A retrospective study of sarcoid uveitis, with a three-year minimum follow-up in Lyon University Hospital between December 2003 and December 2019. Patients presented biopsy-proven sarcoidosis or presumed sarcoid. Recovery was defined by a disease-free status, spontaneously or despite being off all treatments for three years or more. Results: 143 patients were included: 110 with biopsy-proven and 33 with presumed sarcoid uveitis. Seventy-one percent were women, the median age at presentation was 53 years, and 71% were Caucasian. Chronic uveitis was the main clinical presentation (75%), mostly panuveitis (48%) with bilateral involvement (82%). After a median follow-up of 83.5 months, recovery was reported in 26% of patients. In multivariable analysis, Caucasian ethnicity (p = 0.007) and anterior uveitis (p = 0.008) were significantly associated with recovery, while increased intraocular pressure was negatively associated (p = 0.039). Conclusion: In this large European cohort, one quarter of patients recovered. Caucasian ethnicity and anterior uveitis are associated with ocular and extraocular recovery.
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spelling pubmed-77611902020-12-26 Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis Bienvenu, Francois-Henri Tiffet, Théophile Maucort-Boulch, Delphine Gerfaud-Valentin, Mathieu Kodjikian, Laurent Perard, Laurent Burillon, Carole Durel, Cécile-Audrey Hot, Arnaud Jamilloux, Yvan Seve, Pascal J Clin Med Article Background: Sarcoidosis is one of the leading causes of uveitis. To date, no studies have assessed the factors specifically related with recovery in ocular sarcoidosis. In this study, we aimed to determine factors associated with ocular and extraocular recovery in patients with sarcoid uveitis. Methods: A retrospective study of sarcoid uveitis, with a three-year minimum follow-up in Lyon University Hospital between December 2003 and December 2019. Patients presented biopsy-proven sarcoidosis or presumed sarcoid. Recovery was defined by a disease-free status, spontaneously or despite being off all treatments for three years or more. Results: 143 patients were included: 110 with biopsy-proven and 33 with presumed sarcoid uveitis. Seventy-one percent were women, the median age at presentation was 53 years, and 71% were Caucasian. Chronic uveitis was the main clinical presentation (75%), mostly panuveitis (48%) with bilateral involvement (82%). After a median follow-up of 83.5 months, recovery was reported in 26% of patients. In multivariable analysis, Caucasian ethnicity (p = 0.007) and anterior uveitis (p = 0.008) were significantly associated with recovery, while increased intraocular pressure was negatively associated (p = 0.039). Conclusion: In this large European cohort, one quarter of patients recovered. Caucasian ethnicity and anterior uveitis are associated with ocular and extraocular recovery. MDPI 2020-11-30 /pmc/articles/PMC7761190/ /pubmed/33266254 http://dx.doi.org/10.3390/jcm9123894 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bienvenu, Francois-Henri
Tiffet, Théophile
Maucort-Boulch, Delphine
Gerfaud-Valentin, Mathieu
Kodjikian, Laurent
Perard, Laurent
Burillon, Carole
Durel, Cécile-Audrey
Hot, Arnaud
Jamilloux, Yvan
Seve, Pascal
Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title_full Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title_fullStr Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title_full_unstemmed Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title_short Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis
title_sort factors associated with ocular and extraocular recovery in 143 patients with sarcoid uveitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761190/
https://www.ncbi.nlm.nih.gov/pubmed/33266254
http://dx.doi.org/10.3390/jcm9123894
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