Cargando…

BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers

SIMPLE SUMMARY: Women who inherit a BRCAmutation face a high lifetime risk of developing cancer. However, several factors, genetic and/or “environmental”, may influence BRCA penetrance. We studied in 438 women carriers of BRCA1/2 the association of metabolic factors with BRCA1/2 variants and the ris...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliverio, Andreina, Bruno, Eleonora, Colombo, Mara, Paradiso, Angelo, Tommasi, Stefania, Daniele, Antonella, Terribile, Daniela Andreina, Magno, Stefano, Guarino, Donatella, Manoukian, Siranoush, Peissel, Bernard, Radice, Paolo, Pasanisi, Patrizia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761428/ https://www.ncbi.nlm.nih.gov/pubmed/33266155 http://dx.doi.org/10.3390/cancers12123584

Ejemplares similares

The Impact of Mediterranean Dietary Intervention on Metabolic and Hormonal Parameters According to BRCA1/2 Variant Type
por: Oliverio, Andreina, et al.
Publicado: (2022)

A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
por: Bruno, Eleonora, et al.
Publicado: (2020)

Adherence to Mediterranean Diet and Metabolic Syndrome in BRCA Mutation Carriers
por: Bruno, Eleonora, et al.
Publicado: (2017)

A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
por: Pasanisi, Patrizia, et al.
Publicado: (2018)

First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report
por: Ripamonti, Carla B, et al.
Publicado: (2013)

Characterization of an Italian Founder Mutation in the RING-Finger Domain of BRCA1
por: Caleca, Laura, et al.
Publicado: (2014)

Comparative In Vitro and In Silico Analyses of Variants in Splicing Regions of BRCA1 and BRCA2 Genes and Characterization of Novel Pathogenic Mutations
por: Colombo, Mara, et al.
Publicado: (2013)

miRNA deregulation and relationship with metabolic parameters after Mediterranean dietary intervention in BRCA-mutated women
por: De Summa, Simona, et al.
Publicado: (2023)

Sequencing Analysis of SLX4/FANCP Gene in Italian Familial Breast Cancer Cases
por: Catucci, Irene, et al.
Publicado: (2012)

Physical activity and sleep behaviour in women carrying BRCA1/2 mutations
por: Galasso, Letizia, et al.
Publicado: (2022)

Author Correction: Physical activity and sleep behaviour in women carrying BRCA1/2 mutations
por: Galasso, Letizia, et al.
Publicado: (2022)

GFP-Fragment Reassembly Screens for the Functional Characterization of Variants of Uncertain Significance in Protein Interaction Domains of the BRCA1 and BRCA2 Genes
por: Caleca, Laura, et al.
Publicado: (2019)

Analysis of BRCA1 and RAD51C Promoter Methylation in Italian Families at High-Risk of Breast and Ovarian Cancer
por: Tabano, Silvia, et al.
Publicado: (2020)

miR-342 Regulates BRCA1 Expression through Modulation of ID4 in Breast Cancer
por: Crippa, Elisabetta, et al.
Publicado: (2014)

Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review
por: Daniele, A., et al.
Publicado: (2021)

Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer
por: Azzollini, Jacopo, et al.
Publicado: (2019)

Increased access to TP53 analysis through breast cancer multi-gene panels: clinical considerations
por: Azzollini, Jacopo, et al.
Publicado: (2017)

Co-occurrence of Mayer-Rokitansky-Küster-Hauser syndrome and ovarian cancer: A case report and review of the literature
por: Villa, Roberta, et al.
Publicado: (2019)

Revertant mosaicism for family mutations is not observed in BRCA1/2 phenocopies
por: Azzollini, Jacopo, et al.
Publicado: (2017)

Analysis of Italian BRCA1/2 Pathogenic Variants Identifies a Private Spectrum in the Population from the Bergamo Province in Northern Italy
por: Figlioli, Gisella, et al.
Publicado: (2021)

Somatic BRCA Mutation in a Cholangiocarcinoma Patient for HBOC Syndrome Detection
por: Paradiso, Angelo Virgilio, et al.
Publicado: (2020)

Sleep behavior and daily activity levels in people with metabolic syndrome: effect of 1 year of metformin treatment
por: Bruno, Eleonora, et al.
Publicado: (2023)

Corrigendum: Sleep behavior and daily activity levels in people with metabolic syndrome: effect of 1 year of metformin treatment
por: Bruno, Eleonora, et al.
Publicado: (2023)

Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers
por: Eisen, Andrea, et al.
Publicado: (2008)

Prevalence of BRCA homopolymeric indels in an ION Torrent-based tumour-to-germline testing workflow in high-grade ovarian carcinoma
por: Azzollini, Jacopo, et al.
Publicado: (2023)

Management of BRCA Tumour Testing in an Integrated Molecular Tumour Board Multidisciplinary Model
por: Azzollini, Jacopo, et al.
Publicado: (2022)

BRCA mutation carriers’ perceptions on postmenopausal hormone therapy: An Italian study
por: Grandi, Giovanni, et al.
Publicado: (2021)

"Sequencing-grade" screening for BRCA1 variants by oligo-arrays
por: Monaco, Alessandro, et al.
Publicado: (2008)

The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study
por: Iqbal, Javaid, et al.
Publicado: (2016)

BRCA germline mutation test for all woman with ovarian cancer?
por: Paradiso, A. V., et al.
Publicado: (2019)

Usefulness and Limitations of Comprehensive Characterization of mRNA Splicing Profiles in the Definition of the Clinical Relevance of BRCA1/2 Variants of Uncertain Significance
por: Gelli, Elisa, et al.
Publicado: (2019)

Recruitment in randomized clinical trials: The MeMeMe experience
por: Baldassari, Ivan, et al.
Publicado: (2022)

Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction
por: Caleca, Laura, et al.
Publicado: (2018)

Characterization of the HER2 status in BRCA-mutated breast cancer: a single institutional series and systematic review with pooled analysis
por: Tomasello, G., et al.
Publicado: (2022)

Remote vs in-person BRCA1/2 non-carriers test disclosure: patients’ choice during Covid-19 pandemic restriction
por: Costanzo, Silvia, et al.
Publicado: (2022)

A management system for randomized clinical trials: A novel way to supply medication
por: Cortellini, Mauro, et al.
Publicado: (2019)

An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers
por: Osorio, A, et al.
Publicado: (2008)

BRCA1 and BRCA2 mutations in central and southern Italian patients
por: Ottini, Laura, et al.
Publicado: (2000)

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
por: Silvestri, Valentina, et al.
Publicado: (2016)

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
por: Osorio, A, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jr80ub5ip5s9osqqosv36cu8kh