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Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea

Background and objectives: We aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. Materials and methods: We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Kor...

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Autores principales: Kim, Bongyoung, Sohn, Jang Wook, Nam, Soomin, Sohn, Jang Won, Choi, Won Suk, Kim, Hyoung Seop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761510/
https://www.ncbi.nlm.nih.gov/pubmed/33260421
http://dx.doi.org/10.3390/medicina56120659
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author Kim, Bongyoung
Sohn, Jang Wook
Nam, Soomin
Sohn, Jang Won
Choi, Won Suk
Kim, Hyoung Seop
author_facet Kim, Bongyoung
Sohn, Jang Wook
Nam, Soomin
Sohn, Jang Won
Choi, Won Suk
Kim, Hyoung Seop
author_sort Kim, Bongyoung
collection PubMed
description Background and objectives: We aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. Materials and methods: We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). Results: Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8–49 days). The mean period of viral shedding was 23.8 ± 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388–0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. Conclusions: The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity.
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spelling pubmed-77615102020-12-26 Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea Kim, Bongyoung Sohn, Jang Wook Nam, Soomin Sohn, Jang Won Choi, Won Suk Kim, Hyoung Seop Medicina (Kaunas) Article Background and objectives: We aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. Materials and methods: We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). Results: Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8–49 days). The mean period of viral shedding was 23.8 ± 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388–0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. Conclusions: The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity. MDPI 2020-11-29 /pmc/articles/PMC7761510/ /pubmed/33260421 http://dx.doi.org/10.3390/medicina56120659 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Bongyoung
Sohn, Jang Wook
Nam, Soomin
Sohn, Jang Won
Choi, Won Suk
Kim, Hyoung Seop
Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title_full Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title_fullStr Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title_full_unstemmed Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title_short Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
title_sort factors associated with the delayed termination of viral shedding in covid-19 patients with mild severity in south korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761510/
https://www.ncbi.nlm.nih.gov/pubmed/33260421
http://dx.doi.org/10.3390/medicina56120659
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