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Alterations in One-Carbon Metabolism in Celiac Disease

Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted...

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Autores principales: Martín-Masot, Rafael, Mota-Martorell, Natàlia, Jové, Mariona, Maldonado, José, Pamplona, Reinald, Nestares, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761552/
https://www.ncbi.nlm.nih.gov/pubmed/33276620
http://dx.doi.org/10.3390/nu12123723
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author Martín-Masot, Rafael
Mota-Martorell, Natàlia
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
author_facet Martín-Masot, Rafael
Mota-Martorell, Natàlia
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
author_sort Martín-Masot, Rafael
collection PubMed
description Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.
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spelling pubmed-77615522020-12-26 Alterations in One-Carbon Metabolism in Celiac Disease Martín-Masot, Rafael Mota-Martorell, Natàlia Jové, Mariona Maldonado, José Pamplona, Reinald Nestares, Teresa Nutrients Article Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD. MDPI 2020-12-02 /pmc/articles/PMC7761552/ /pubmed/33276620 http://dx.doi.org/10.3390/nu12123723 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martín-Masot, Rafael
Mota-Martorell, Natàlia
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
Alterations in One-Carbon Metabolism in Celiac Disease
title Alterations in One-Carbon Metabolism in Celiac Disease
title_full Alterations in One-Carbon Metabolism in Celiac Disease
title_fullStr Alterations in One-Carbon Metabolism in Celiac Disease
title_full_unstemmed Alterations in One-Carbon Metabolism in Celiac Disease
title_short Alterations in One-Carbon Metabolism in Celiac Disease
title_sort alterations in one-carbon metabolism in celiac disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761552/
https://www.ncbi.nlm.nih.gov/pubmed/33276620
http://dx.doi.org/10.3390/nu12123723
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