Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury

A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determ...

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Autores principales: P. Drasites, Kelsey, Shams, Ramsha, Zaman, Vandana, Matzelle, Denise, C. Shields, Donald, P. Garner, Dena, J. Sole, Christopher, Haque, Azizul, Banik, Narendra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761577/
https://www.ncbi.nlm.nih.gov/pubmed/33276534
http://dx.doi.org/10.3390/brainsci10120933
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author P. Drasites, Kelsey
Shams, Ramsha
Zaman, Vandana
Matzelle, Denise
C. Shields, Donald
P. Garner, Dena
J. Sole, Christopher
Haque, Azizul
Banik, Narendra L.
author_facet P. Drasites, Kelsey
Shams, Ramsha
Zaman, Vandana
Matzelle, Denise
C. Shields, Donald
P. Garner, Dena
J. Sole, Christopher
Haque, Azizul
Banik, Narendra L.
author_sort P. Drasites, Kelsey
collection PubMed
description A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determine the best options to salvage affected musculature before it is lost. These approaches include pharmacotherapeutic options, immunosuppressants, physical activity or a combination thereof. Associated biomarkers are increasingly used to determine if these treatments aid in the protection and reconstruction of affected musculature.
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spelling pubmed-77615772020-12-26 Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury P. Drasites, Kelsey Shams, Ramsha Zaman, Vandana Matzelle, Denise C. Shields, Donald P. Garner, Dena J. Sole, Christopher Haque, Azizul Banik, Narendra L. Brain Sci Review A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determine the best options to salvage affected musculature before it is lost. These approaches include pharmacotherapeutic options, immunosuppressants, physical activity or a combination thereof. Associated biomarkers are increasingly used to determine if these treatments aid in the protection and reconstruction of affected musculature. MDPI 2020-12-02 /pmc/articles/PMC7761577/ /pubmed/33276534 http://dx.doi.org/10.3390/brainsci10120933 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
P. Drasites, Kelsey
Shams, Ramsha
Zaman, Vandana
Matzelle, Denise
C. Shields, Donald
P. Garner, Dena
J. Sole, Christopher
Haque, Azizul
Banik, Narendra L.
Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title_full Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title_fullStr Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title_full_unstemmed Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title_short Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury
title_sort pathophysiology, biomarkers, and therapeutic modalities associated with skeletal muscle loss following spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761577/
https://www.ncbi.nlm.nih.gov/pubmed/33276534
http://dx.doi.org/10.3390/brainsci10120933
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