Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were c...

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Autores principales: Spina, Edoardo, Barbieri, Maria Antonietta, Cicala, Giuseppe, de Leon, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761579/
https://www.ncbi.nlm.nih.gov/pubmed/33276675
http://dx.doi.org/10.3390/ph13120439
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author Spina, Edoardo
Barbieri, Maria Antonietta
Cicala, Giuseppe
de Leon, Jose
author_facet Spina, Edoardo
Barbieri, Maria Antonietta
Cicala, Giuseppe
de Leon, Jose
author_sort Spina, Edoardo
collection PubMed
description This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available.
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spelling pubmed-77615792020-12-26 Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents Spina, Edoardo Barbieri, Maria Antonietta Cicala, Giuseppe de Leon, Jose Pharmaceuticals (Basel) Review This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available. MDPI 2020-12-02 /pmc/articles/PMC7761579/ /pubmed/33276675 http://dx.doi.org/10.3390/ph13120439 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Spina, Edoardo
Barbieri, Maria Antonietta
Cicala, Giuseppe
de Leon, Jose
Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title_full Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title_fullStr Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title_full_unstemmed Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title_short Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
title_sort clinically relevant interactions between atypical antipsychotics and anti-infective agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761579/
https://www.ncbi.nlm.nih.gov/pubmed/33276675
http://dx.doi.org/10.3390/ph13120439
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