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Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting

While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited im...

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Autores principales: Cole, Leah E., Zhang, Jinrong, Pacheco, Kristl M., Lhéritier, Philippe, Anosova, Natalie G., Piolat, Julie, Zheng, Lingyi, Reveneau, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761625/
https://www.ncbi.nlm.nih.gov/pubmed/33276673
http://dx.doi.org/10.3390/vaccines8040729
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author Cole, Leah E.
Zhang, Jinrong
Pacheco, Kristl M.
Lhéritier, Philippe
Anosova, Natalie G.
Piolat, Julie
Zheng, Lingyi
Reveneau, Nathalie
author_facet Cole, Leah E.
Zhang, Jinrong
Pacheco, Kristl M.
Lhéritier, Philippe
Anosova, Natalie G.
Piolat, Julie
Zheng, Lingyi
Reveneau, Nathalie
author_sort Cole, Leah E.
collection PubMed
description While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited immune responses, pre-adult baboons were immunized with either aP or wP vaccines, boosted with an aP vaccine, and observed over a nearly two-year period. Priming with a wP vaccine elicited a more Th17-biased response than priming with aP, whereas priming with an aP vaccine led to a more Th2-biased response than priming with wP. These differences were maintained after aP vaccine boost immunizations. Compared to aP, animals primed with a wP vaccine exhibited greater numbers of pertussis specific memory B cells. While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. Both wP and aP vaccine immunization could induce serum bactericidal activity (SBA); however, only one wP vaccine immunization was required to elicit SBA while multiple aP vaccine immunizations were required to elicit lower, less durable SBA titers. In conclusion, when compared to aP vaccine, priming with wP vaccine elicits distinct cellular and humoral immune responses that persist after aP vaccine boosting.
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spelling pubmed-77616252020-12-26 Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting Cole, Leah E. Zhang, Jinrong Pacheco, Kristl M. Lhéritier, Philippe Anosova, Natalie G. Piolat, Julie Zheng, Lingyi Reveneau, Nathalie Vaccines (Basel) Article While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited immune responses, pre-adult baboons were immunized with either aP or wP vaccines, boosted with an aP vaccine, and observed over a nearly two-year period. Priming with a wP vaccine elicited a more Th17-biased response than priming with aP, whereas priming with an aP vaccine led to a more Th2-biased response than priming with wP. These differences were maintained after aP vaccine boost immunizations. Compared to aP, animals primed with a wP vaccine exhibited greater numbers of pertussis specific memory B cells. While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. Both wP and aP vaccine immunization could induce serum bactericidal activity (SBA); however, only one wP vaccine immunization was required to elicit SBA while multiple aP vaccine immunizations were required to elicit lower, less durable SBA titers. In conclusion, when compared to aP vaccine, priming with wP vaccine elicits distinct cellular and humoral immune responses that persist after aP vaccine boosting. MDPI 2020-12-02 /pmc/articles/PMC7761625/ /pubmed/33276673 http://dx.doi.org/10.3390/vaccines8040729 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cole, Leah E.
Zhang, Jinrong
Pacheco, Kristl M.
Lhéritier, Philippe
Anosova, Natalie G.
Piolat, Julie
Zheng, Lingyi
Reveneau, Nathalie
Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title_full Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title_fullStr Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title_full_unstemmed Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title_short Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
title_sort immunological distinctions between acellular and whole-cell pertussis immunizations of baboons persist for at least one year after acellular vaccine boosting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761625/
https://www.ncbi.nlm.nih.gov/pubmed/33276673
http://dx.doi.org/10.3390/vaccines8040729
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