Cargando…
Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting
While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited im...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761625/ https://www.ncbi.nlm.nih.gov/pubmed/33276673 http://dx.doi.org/10.3390/vaccines8040729 |
_version_ | 1783627612439969792 |
---|---|
author | Cole, Leah E. Zhang, Jinrong Pacheco, Kristl M. Lhéritier, Philippe Anosova, Natalie G. Piolat, Julie Zheng, Lingyi Reveneau, Nathalie |
author_facet | Cole, Leah E. Zhang, Jinrong Pacheco, Kristl M. Lhéritier, Philippe Anosova, Natalie G. Piolat, Julie Zheng, Lingyi Reveneau, Nathalie |
author_sort | Cole, Leah E. |
collection | PubMed |
description | While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited immune responses, pre-adult baboons were immunized with either aP or wP vaccines, boosted with an aP vaccine, and observed over a nearly two-year period. Priming with a wP vaccine elicited a more Th17-biased response than priming with aP, whereas priming with an aP vaccine led to a more Th2-biased response than priming with wP. These differences were maintained after aP vaccine boost immunizations. Compared to aP, animals primed with a wP vaccine exhibited greater numbers of pertussis specific memory B cells. While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. Both wP and aP vaccine immunization could induce serum bactericidal activity (SBA); however, only one wP vaccine immunization was required to elicit SBA while multiple aP vaccine immunizations were required to elicit lower, less durable SBA titers. In conclusion, when compared to aP vaccine, priming with wP vaccine elicits distinct cellular and humoral immune responses that persist after aP vaccine boosting. |
format | Online Article Text |
id | pubmed-7761625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77616252020-12-26 Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting Cole, Leah E. Zhang, Jinrong Pacheco, Kristl M. Lhéritier, Philippe Anosova, Natalie G. Piolat, Julie Zheng, Lingyi Reveneau, Nathalie Vaccines (Basel) Article While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited immune responses, pre-adult baboons were immunized with either aP or wP vaccines, boosted with an aP vaccine, and observed over a nearly two-year period. Priming with a wP vaccine elicited a more Th17-biased response than priming with aP, whereas priming with an aP vaccine led to a more Th2-biased response than priming with wP. These differences were maintained after aP vaccine boost immunizations. Compared to aP, animals primed with a wP vaccine exhibited greater numbers of pertussis specific memory B cells. While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. Both wP and aP vaccine immunization could induce serum bactericidal activity (SBA); however, only one wP vaccine immunization was required to elicit SBA while multiple aP vaccine immunizations were required to elicit lower, less durable SBA titers. In conclusion, when compared to aP vaccine, priming with wP vaccine elicits distinct cellular and humoral immune responses that persist after aP vaccine boosting. MDPI 2020-12-02 /pmc/articles/PMC7761625/ /pubmed/33276673 http://dx.doi.org/10.3390/vaccines8040729 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cole, Leah E. Zhang, Jinrong Pacheco, Kristl M. Lhéritier, Philippe Anosova, Natalie G. Piolat, Julie Zheng, Lingyi Reveneau, Nathalie Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title | Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title_full | Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title_fullStr | Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title_full_unstemmed | Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title_short | Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting |
title_sort | immunological distinctions between acellular and whole-cell pertussis immunizations of baboons persist for at least one year after acellular vaccine boosting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761625/ https://www.ncbi.nlm.nih.gov/pubmed/33276673 http://dx.doi.org/10.3390/vaccines8040729 |
work_keys_str_mv | AT coleleahe immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT zhangjinrong immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT pachecokristlm immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT lheritierphilippe immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT anosovanatalieg immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT piolatjulie immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT zhenglingyi immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting AT reveneaunathalie immunologicaldistinctionsbetweenacellularandwholecellpertussisimmunizationsofbaboonspersistforatleastoneyearafteracellularvaccineboosting |