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The Role of Adrenoceptors in the Retina

The retina is a part of the central nervous system, a thin multilayer with neuronal lamination, responsible for detecting, preprocessing, and sending visual information to the brain. Many retinal diseases are characterized by hemodynamic perturbations and neurodegeneration leading to vision loss and...

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Detalles Bibliográficos
Autores principales: Ruan, Yue, Böhmer, Tobias, Jiang, Subao, Gericke, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761662/
https://www.ncbi.nlm.nih.gov/pubmed/33287335
http://dx.doi.org/10.3390/cells9122594
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author Ruan, Yue
Böhmer, Tobias
Jiang, Subao
Gericke, Adrian
author_facet Ruan, Yue
Böhmer, Tobias
Jiang, Subao
Gericke, Adrian
author_sort Ruan, Yue
collection PubMed
description The retina is a part of the central nervous system, a thin multilayer with neuronal lamination, responsible for detecting, preprocessing, and sending visual information to the brain. Many retinal diseases are characterized by hemodynamic perturbations and neurodegeneration leading to vision loss and reduced quality of life. Since catecholamines and respective bindings sites have been characterized in the retina, we systematically reviewed the literature with regard to retinal expression, distribution and function of alpha(1) (α(1))-, alpha(2) (α(2))-, and beta (β)-adrenoceptors (ARs). Moreover, we discuss the role of the individual adrenoceptors as targets for the treatment of retinal diseases.
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spelling pubmed-77616622020-12-26 The Role of Adrenoceptors in the Retina Ruan, Yue Böhmer, Tobias Jiang, Subao Gericke, Adrian Cells Review The retina is a part of the central nervous system, a thin multilayer with neuronal lamination, responsible for detecting, preprocessing, and sending visual information to the brain. Many retinal diseases are characterized by hemodynamic perturbations and neurodegeneration leading to vision loss and reduced quality of life. Since catecholamines and respective bindings sites have been characterized in the retina, we systematically reviewed the literature with regard to retinal expression, distribution and function of alpha(1) (α(1))-, alpha(2) (α(2))-, and beta (β)-adrenoceptors (ARs). Moreover, we discuss the role of the individual adrenoceptors as targets for the treatment of retinal diseases. MDPI 2020-12-03 /pmc/articles/PMC7761662/ /pubmed/33287335 http://dx.doi.org/10.3390/cells9122594 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ruan, Yue
Böhmer, Tobias
Jiang, Subao
Gericke, Adrian
The Role of Adrenoceptors in the Retina
title The Role of Adrenoceptors in the Retina
title_full The Role of Adrenoceptors in the Retina
title_fullStr The Role of Adrenoceptors in the Retina
title_full_unstemmed The Role of Adrenoceptors in the Retina
title_short The Role of Adrenoceptors in the Retina
title_sort role of adrenoceptors in the retina
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761662/
https://www.ncbi.nlm.nih.gov/pubmed/33287335
http://dx.doi.org/10.3390/cells9122594
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