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Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate

SIMPLE SUMMARY: This study was conducted to examine how ergovaline/ergovalinine ingestion during pregnancy in ewes with different DRD2 genotypes altered ewe and lamb performance. Feeding ergovaline/ergovalinine in last trimester reduced lamb birth weight; however, milk production was lower for all e...

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Autores principales: Britt, Jessica L., Greene, Maslyn A., Wilbanks, Sarah A., Bertrand, J. Keith, Klotz, James L., Bridges, William, Aiken, Glen, Andrae, John G., Duckett, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761808/
https://www.ncbi.nlm.nih.gov/pubmed/33287449
http://dx.doi.org/10.3390/ani10122291
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author Britt, Jessica L.
Greene, Maslyn A.
Wilbanks, Sarah A.
Bertrand, J. Keith
Klotz, James L.
Bridges, William
Aiken, Glen
Andrae, John G.
Duckett, Susan K.
author_facet Britt, Jessica L.
Greene, Maslyn A.
Wilbanks, Sarah A.
Bertrand, J. Keith
Klotz, James L.
Bridges, William
Aiken, Glen
Andrae, John G.
Duckett, Susan K.
author_sort Britt, Jessica L.
collection PubMed
description SIMPLE SUMMARY: This study was conducted to examine how ergovaline/ergovalinine ingestion during pregnancy in ewes with different DRD2 genotypes altered ewe and lamb performance. Feeding ergovaline/ergovalinine in last trimester reduced lamb birth weight; however, milk production was lower for all ewes fed ergovaline/ergovalinine. Lambs born to dams fed ergovaline/ergovalinine had slower growth rates and lower weaning weights. These results demonstrate that ingestion of ergot alkaloids during pregnancy can negatively influence lactation, growth of offspring and birth and weaning weights. Recommendations would include strategies to mitigate mycotoxin exposure in pregnant ewes to improve production. ABSTRACT: Endophyte-infected tall fescue (E+) produces ergovaline and ergovalinine, which are mycotoxins that act as dopamine agonists to suppress prolactin and induce vasoconstriction. The experiment was designed as a 3 × 2 × 2 factorial with DRD2 genotype (AA, AG, GG), fescue seed (endophyte-free, E− or endophyte-infected, E+), stage of gestation (MID, d (day) 35–85; LATE, d 86–parturition) and all interactions in the model. Pregnant Suffolk ewes (n = 60) were stratified by genotype and fed E+ or E− seed in a total mixed ration according to treatment assignment. Serum prolactin concentrations were lower (p < 0.05) in ewes fed E+ seed but did not differ by maternal DRD2 genotype or two-way interaction. Lamb birth weight was lower (p < 0.05) in ewes fed E+ seed in last trimester. Pre-weaning growth rate, milk production and total weaning weight was reduced (p < 0.05) in ewes fed E+ fescue seed during MID and LATE gestation. Ingestion of ergovaline/ergovalinine in last trimester reduces lamb birth weight; however, lamb growth rate, milk production and total weaning weight are reduced in all ewes fed E+ during mid and last trimester.
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spelling pubmed-77618082020-12-26 Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate Britt, Jessica L. Greene, Maslyn A. Wilbanks, Sarah A. Bertrand, J. Keith Klotz, James L. Bridges, William Aiken, Glen Andrae, John G. Duckett, Susan K. Animals (Basel) Article SIMPLE SUMMARY: This study was conducted to examine how ergovaline/ergovalinine ingestion during pregnancy in ewes with different DRD2 genotypes altered ewe and lamb performance. Feeding ergovaline/ergovalinine in last trimester reduced lamb birth weight; however, milk production was lower for all ewes fed ergovaline/ergovalinine. Lambs born to dams fed ergovaline/ergovalinine had slower growth rates and lower weaning weights. These results demonstrate that ingestion of ergot alkaloids during pregnancy can negatively influence lactation, growth of offspring and birth and weaning weights. Recommendations would include strategies to mitigate mycotoxin exposure in pregnant ewes to improve production. ABSTRACT: Endophyte-infected tall fescue (E+) produces ergovaline and ergovalinine, which are mycotoxins that act as dopamine agonists to suppress prolactin and induce vasoconstriction. The experiment was designed as a 3 × 2 × 2 factorial with DRD2 genotype (AA, AG, GG), fescue seed (endophyte-free, E− or endophyte-infected, E+), stage of gestation (MID, d (day) 35–85; LATE, d 86–parturition) and all interactions in the model. Pregnant Suffolk ewes (n = 60) were stratified by genotype and fed E+ or E− seed in a total mixed ration according to treatment assignment. Serum prolactin concentrations were lower (p < 0.05) in ewes fed E+ seed but did not differ by maternal DRD2 genotype or two-way interaction. Lamb birth weight was lower (p < 0.05) in ewes fed E+ seed in last trimester. Pre-weaning growth rate, milk production and total weaning weight was reduced (p < 0.05) in ewes fed E+ fescue seed during MID and LATE gestation. Ingestion of ergovaline/ergovalinine in last trimester reduces lamb birth weight; however, lamb growth rate, milk production and total weaning weight are reduced in all ewes fed E+ during mid and last trimester. MDPI 2020-12-03 /pmc/articles/PMC7761808/ /pubmed/33287449 http://dx.doi.org/10.3390/ani10122291 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Britt, Jessica L.
Greene, Maslyn A.
Wilbanks, Sarah A.
Bertrand, J. Keith
Klotz, James L.
Bridges, William
Aiken, Glen
Andrae, John G.
Duckett, Susan K.
Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title_full Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title_fullStr Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title_full_unstemmed Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title_short Feeding Tall Fescue Seed Reduces Ewe Milk Production, Lamb Birth Weight and Pre-Weaning Growth Rate
title_sort feeding tall fescue seed reduces ewe milk production, lamb birth weight and pre-weaning growth rate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761808/
https://www.ncbi.nlm.nih.gov/pubmed/33287449
http://dx.doi.org/10.3390/ani10122291
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