Cargando…
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR
Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely used to treat asthma disorders, while CysLT2R is a po...
Autores principales: | Sadybekov, Arman A., Brouillette, Rebecca L., Marin, Egor, Sadybekov, Anastasiia V., Luginina, Aleksandra, Gusach, Anastasiia, Mishin, Alexey, Besserer-Offroy, Élie, Longpré, Jean-Michel, Borshchevskiy, Valentin, Cherezov, Vadim, Sarret, Philippe, Katritch, Vsevolod |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761830/ https://www.ncbi.nlm.nih.gov/pubmed/33287369 http://dx.doi.org/10.3390/biom10121634 |
Ejemplares similares
-
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
por: Gusach, Anastasiia, et al.
Publicado: (2019) -
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
por: Luginina, Aleksandra, et al.
Publicado: (2019) -
Breaking the Enigma Code of Angiotensin II Type 2 Receptor Signaling
por: Sadybekov, Anastasiia, et al.
Publicado: (2020) -
Structural insights on ligand recognition at the human leukotriene B4 receptor 1
por: Michaelian, Nairie, et al.
Publicado: (2021) -
An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio
por: Sadybekov, Anastasiia, et al.
Publicado: (2017)