Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors

SIMPLE SUMMARY: siRNA delivery to tumor endothelial cells was achieved using arginyl-glycyl-aspartic acid (RGD)-modified lipid nanoparticles containing a novel pH-sensitive and biodegradable lipid. The anti-tumor efficacy of an immune checkpoint inhibitor was improved by the silencing of VEGFR2 usin...

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Detalles Bibliográficos
Autores principales: Cho, Riki, Sakurai, Yu, Jones, Haleigh Sakura, Akita, Hidetaka, Hisaka, Akihiro, Hatakeyama, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761875/
https://www.ncbi.nlm.nih.gov/pubmed/33291555
http://dx.doi.org/10.3390/cancers12123630

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