Cargando…

Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

SIMPLE SUMMARY: Therapeutic targeting of Wnt has long been suggested for gastrointestinal (GI) cancer treatment because deregulation of Wnt signaling is associated with GI cancers. However, therapeutic targeting of Wnt is still challenging because of the pleiotropic roles of Wnt signaling in the hum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Moon Jong, Huang, Yuanjian, Park, Jae-Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761926/ https://www.ncbi.nlm.nih.gov/pubmed/33291655 http://dx.doi.org/10.3390/cancers12123638

Ejemplares similares

A New Wave of Targeting ‘Undruggable’ Wnt Signaling for Cancer Therapy: Challenges and Opportunities
por: Park, Woo-Jung, et al.
Publicado: (2023)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies
por: Yang, Ke, et al.
Publicado: (2015)

Wnt signaling in liver regeneration, disease, and cancer
por: Zou, Gengyi, et al.
Publicado: (2023)

Our evolving view of Wnt signaling in C. elegans: If two’s company and three’s a crowd, is four really necessary?
por: Robertson, Scott M., et al.
Publicado: (2012)

Cross-Talk between Wnt Signaling and Src Tyrosine Kinase
por: Min, Jung Ki, et al.
Publicado: (2022)

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

Wnt Signaling and Aging of the Gastrointestinal Tract
por: Asano, Naoki, et al.
Publicado: (2022)

Evolving views of involution
por: Master, Stephen R, et al.
Publicado: (2004)

The Evolving View of Astrocytes
por: Haydon, Philip G.
Publicado: (2016)

Wnt/β-catenin signaling in cancers and targeted therapies
por: Yu, Fanyuan, et al.
Publicado: (2021)

Wnt Signalling in Gastrointestinal Epithelial Stem Cells
por: Flanagan, Dustin J., et al.
Publicado: (2018)

LIG4 mediates Wnt signalling-induced radioresistance
por: Jun, Sohee, et al.
Publicado: (2016)

Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
por: McCord, Matthew, et al.
Publicado: (2017)

Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
por: Jridi, Imen, et al.
Publicado: (2021)

The Evolving View of Uremic Toxicity
por: Meijers, Bjorn, et al.
Publicado: (2022)

Wnt signaling: a promising target for osteoarthritis therapy
por: Wang, Yudan, et al.
Publicado: (2019)

Mammary stem cells and cancer: roles of Wnt signaling in plain view
por: Many, Alexander M, et al.
Publicado: (2010)

Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
por: Najafi, S Mahmoud A
Publicado: (2020)

Harnessing Wnt signaling as a targetable therapy in epithelial ovarian cancer
por: Wall, Jaclyn A., et al.
Publicado: (2020)

An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond
por: Iverson, T.M., et al.
Publicado: (2023)

Targeting Wnt Signaling in Endometrial Cancer
por: Fatima, Iram, et al.
Publicado: (2021)

Gastrointestinal Stromal Tumor – An Evolving Concept
por: Tornillo, Luigi
Publicado: (2014)

Evolving targets for lipid-modifying therapy
por: Do, Rose Q, et al.
Publicado: (2014)

Impact of homeobox genes in gastrointestinal cancer
por: Joo, Moon Kyung, et al.
Publicado: (2016)

Evolving Clinical Utility of Liquid Biopsy in Gastrointestinal Cancers
por: Jacobson, Richard A., et al.
Publicado: (2019)

The rapidly evolving view of lysosomal storage diseases
por: Parenti, Giancarlo, et al.
Publicado: (2021)

The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy
por: Wang, Zhuo, et al.
Publicado: (2021)

EGFR targeted therapy in lung cancer; an evolving story
por: Bartholomew, C., et al.
Publicado: (2017)

Targeting Wnt Signaling for the Treatment of Gastric Cancer
por: Koushyar, Sarah, et al.
Publicado: (2020)

Evolving role of artificial intelligence in gastrointestinal endoscopy
por: Parasher, Gulshan, et al.
Publicado: (2020)

Targeting the Wnt pathways for therapies
por: Blagodatski, Artem, et al.
Publicado: (2014)

Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition
por: Flanagan, Dustin J., et al.
Publicado: (2022)

A neutral view of the evolving genomic architecture of speciation
por: Southcott, Laura, et al.
Publicado: (2017)

The evolving view of replay and its functions in wake and sleep
por: Findlay, Graham, et al.
Publicado: (2021)

Recurrent Non-Variceal Upper Gastrointestinal Bleeding among Patients Receiving Dual Antiplatelet Therapy
por: Yoo, Ah Young, et al.
Publicado: (2023)

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity
por: Muñoz-Bravo, Jose Luis, et al.
Publicado: (2016)

Targeted Therapies in Advanced Biliary Tract Cancer: An Evolving Paradigm
por: Chakrabarti, Sakti, et al.
Publicado: (2020)

Relevance of Wnt signaling for osteoanabolic therapy
por: Yorgan, Timur A, et al.
Publicado: (2014)

The Wnt Signalling Pathway: A Tailored Target in Cancer
por: Koni, Malvina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tan6gh94r5r97eertj4sbeig3a