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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals wi...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761941/ https://www.ncbi.nlm.nih.gov/pubmed/33291602 http://dx.doi.org/10.3390/md18120619 |
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author | Barreca, Marilia Spanò, Virginia Montalbano, Alessandra Cueto, Mercedes Díaz Marrero, Ana R. Deniz, Irem Erdoğan, Ayşegül Lukić Bilela, Lada Moulin, Corentin Taffin-de-Givenchy, Elisabeth Spriano, Filippo Perale, Giuseppe Mehiri, Mohamed Rotter, Ana P. Thomas, Olivier Barraja, Paola Gaudêncio, Susana P. Bertoni, Francesco |
author_facet | Barreca, Marilia Spanò, Virginia Montalbano, Alessandra Cueto, Mercedes Díaz Marrero, Ana R. Deniz, Irem Erdoğan, Ayşegül Lukić Bilela, Lada Moulin, Corentin Taffin-de-Givenchy, Elisabeth Spriano, Filippo Perale, Giuseppe Mehiri, Mohamed Rotter, Ana P. Thomas, Olivier Barraja, Paola Gaudêncio, Susana P. Bertoni, Francesco |
author_sort | Barreca, Marilia |
collection | PubMed |
description | The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. |
format | Online Article Text |
id | pubmed-7761941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77619412020-12-26 Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes Barreca, Marilia Spanò, Virginia Montalbano, Alessandra Cueto, Mercedes Díaz Marrero, Ana R. Deniz, Irem Erdoğan, Ayşegül Lukić Bilela, Lada Moulin, Corentin Taffin-de-Givenchy, Elisabeth Spriano, Filippo Perale, Giuseppe Mehiri, Mohamed Rotter, Ana P. Thomas, Olivier Barraja, Paola Gaudêncio, Susana P. Bertoni, Francesco Mar Drugs Review The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. MDPI 2020-12-04 /pmc/articles/PMC7761941/ /pubmed/33291602 http://dx.doi.org/10.3390/md18120619 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barreca, Marilia Spanò, Virginia Montalbano, Alessandra Cueto, Mercedes Díaz Marrero, Ana R. Deniz, Irem Erdoğan, Ayşegül Lukić Bilela, Lada Moulin, Corentin Taffin-de-Givenchy, Elisabeth Spriano, Filippo Perale, Giuseppe Mehiri, Mohamed Rotter, Ana P. Thomas, Olivier Barraja, Paola Gaudêncio, Susana P. Bertoni, Francesco Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title | Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title_full | Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title_fullStr | Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title_full_unstemmed | Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title_short | Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes |
title_sort | marine anticancer agents: an overview with a particular focus on their chemical classes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761941/ https://www.ncbi.nlm.nih.gov/pubmed/33291602 http://dx.doi.org/10.3390/md18120619 |
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