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Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study
SIMPLE SUMMARY: Papillary thyroid cancer (PTC) patients are staged according to the Tumor-Node-Metastasis staging system (TNM). This work was aimed at comparing the usefulness of the 8th edition of TNM (TNM-8), currently used, and that of the previous one (TNM-7) for predicting disease-free interval...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761952/ https://www.ncbi.nlm.nih.gov/pubmed/33291668 http://dx.doi.org/10.3390/cancers12123637 |
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author | Sorrenti, Salvatore Carbotta, Giovanni Di Matteo, Filippo Maria Catania, Antonio Pironi, Daniele Tartaglia, Francesco Tarroni, Danilo Gagliardi, Federica Tripodi, Domenico Watanabe, Mikiko Mariani, Stefania D’Armiento, Eleonora Fallahi, Poupak Sindoni, Alessandro De Vito, Corrado Antonelli, Alessandro Ulisse, Salvatore Baldini, Enke |
author_facet | Sorrenti, Salvatore Carbotta, Giovanni Di Matteo, Filippo Maria Catania, Antonio Pironi, Daniele Tartaglia, Francesco Tarroni, Danilo Gagliardi, Federica Tripodi, Domenico Watanabe, Mikiko Mariani, Stefania D’Armiento, Eleonora Fallahi, Poupak Sindoni, Alessandro De Vito, Corrado Antonelli, Alessandro Ulisse, Salvatore Baldini, Enke |
author_sort | Sorrenti, Salvatore |
collection | PubMed |
description | SIMPLE SUMMARY: Papillary thyroid cancer (PTC) patients are staged according to the Tumor-Node-Metastasis staging system (TNM). This work was aimed at comparing the usefulness of the 8th edition of TNM (TNM-8), currently used, and that of the previous one (TNM-7) for predicting disease-free interval (DFI) in a cohort of 1148 patients. Moreover, clinicopathological and molecular factors were statistically evaluated in order to determine which of these was/were the best predictor(s) of DFI. Results obtained from the multivariate analysis indicated that advanced tumor stages were independent risk factors for a lower DFI regardless of TNM, but the statistical model created with the TNM-7 was most accurate. When stage-determining factors were included individually in the multivariate analysis, LN metastases, tall cell variant, and age emerged as independent risk factors for a shorter DFI, with lateral LN metastases being the most relevant. No molecular parameters could improve the prediction of DFI provided by LN metastases. ABSTRACT: The American Joint Committee on Cancer has revised the Tumor-Node-Metastasis (TNM) staging system for papillary thyroid cancer (PTC) patients. We examined the impact of this new classification (TNM-8) on patient stratification and estimated the prognostic value of clinicopathological features for the disease-free interval (DFI) in a cohort of 1148 PTC patients. Kaplan–Meier analyses showed that all clinicopathological parameters analyzed, except age and multifocality, were associated significantly with DFI. Cox regression identified tall cell PTC variant and stage as independent risk factors for DFI. When the stage was replaced with age, tumor size, and lymph node (LN) metastases in the set of covariates, the lateral LN metastases stood out as the strongest independent predictor of DFI, followed by tall cell variant and age. A noteworthy result emerging from these analyzes is that regression models had lower Akaike and Bayesian information criterions if variables were categorized based on the TNM-7. In addition, we examined data from a different PTC patient cohort, acquired from The Cancer Genome Atlas database, to verify whether the DFI prediction could be enhanced by further clinicopathological and molecular parameters. However, none of these was found to be a significant predictor of DFI in the Cox model. |
format | Online Article Text |
id | pubmed-7761952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77619522020-12-26 Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study Sorrenti, Salvatore Carbotta, Giovanni Di Matteo, Filippo Maria Catania, Antonio Pironi, Daniele Tartaglia, Francesco Tarroni, Danilo Gagliardi, Federica Tripodi, Domenico Watanabe, Mikiko Mariani, Stefania D’Armiento, Eleonora Fallahi, Poupak Sindoni, Alessandro De Vito, Corrado Antonelli, Alessandro Ulisse, Salvatore Baldini, Enke Cancers (Basel) Article SIMPLE SUMMARY: Papillary thyroid cancer (PTC) patients are staged according to the Tumor-Node-Metastasis staging system (TNM). This work was aimed at comparing the usefulness of the 8th edition of TNM (TNM-8), currently used, and that of the previous one (TNM-7) for predicting disease-free interval (DFI) in a cohort of 1148 patients. Moreover, clinicopathological and molecular factors were statistically evaluated in order to determine which of these was/were the best predictor(s) of DFI. Results obtained from the multivariate analysis indicated that advanced tumor stages were independent risk factors for a lower DFI regardless of TNM, but the statistical model created with the TNM-7 was most accurate. When stage-determining factors were included individually in the multivariate analysis, LN metastases, tall cell variant, and age emerged as independent risk factors for a shorter DFI, with lateral LN metastases being the most relevant. No molecular parameters could improve the prediction of DFI provided by LN metastases. ABSTRACT: The American Joint Committee on Cancer has revised the Tumor-Node-Metastasis (TNM) staging system for papillary thyroid cancer (PTC) patients. We examined the impact of this new classification (TNM-8) on patient stratification and estimated the prognostic value of clinicopathological features for the disease-free interval (DFI) in a cohort of 1148 PTC patients. Kaplan–Meier analyses showed that all clinicopathological parameters analyzed, except age and multifocality, were associated significantly with DFI. Cox regression identified tall cell PTC variant and stage as independent risk factors for DFI. When the stage was replaced with age, tumor size, and lymph node (LN) metastases in the set of covariates, the lateral LN metastases stood out as the strongest independent predictor of DFI, followed by tall cell variant and age. A noteworthy result emerging from these analyzes is that regression models had lower Akaike and Bayesian information criterions if variables were categorized based on the TNM-7. In addition, we examined data from a different PTC patient cohort, acquired from The Cancer Genome Atlas database, to verify whether the DFI prediction could be enhanced by further clinicopathological and molecular parameters. However, none of these was found to be a significant predictor of DFI in the Cox model. MDPI 2020-12-04 /pmc/articles/PMC7761952/ /pubmed/33291668 http://dx.doi.org/10.3390/cancers12123637 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sorrenti, Salvatore Carbotta, Giovanni Di Matteo, Filippo Maria Catania, Antonio Pironi, Daniele Tartaglia, Francesco Tarroni, Danilo Gagliardi, Federica Tripodi, Domenico Watanabe, Mikiko Mariani, Stefania D’Armiento, Eleonora Fallahi, Poupak Sindoni, Alessandro De Vito, Corrado Antonelli, Alessandro Ulisse, Salvatore Baldini, Enke Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title | Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title_full | Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title_fullStr | Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title_full_unstemmed | Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title_short | Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study |
title_sort | evaluation of clinicopathological and molecular parameters on disease recurrence of papillary thyroid cancer patient: a retrospective observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761952/ https://www.ncbi.nlm.nih.gov/pubmed/33291668 http://dx.doi.org/10.3390/cancers12123637 |
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