Clinical Feasibility of a High-Resolution Thermal Monitoring Sheet for Superficial Hyperthermia in Breast Cancer Patients

SIMPLE SUMMARY: Hyperthermia, i.e., heating tumors to 41–43 °C, combined with radiotherapy improves treatment response, for patients with recurrent breast cancer after previous irradiation. During hyperthermia of superficial tumors, the skin surface temperature must be monitored to ensure that therapeutic temperatures are reached without hotspots that can cause additional toxicity. A thin sheet with a dense grid of 56 temperature sensors was developed, this sheet is placed on the skin of the patient. The influence of the sheet on the hyperthermia applicator performance was investigated and found to be negligible. Next, the clinical feasibility was evaluated in 10 women with locoregional recurrent breast cancer, and resulted in precise monitoring of skin surface temperatures. In conclusion, this novel method can be implemented for thermal monitoring of the skin surface to ensure treatment quality during superficial hyperthermia treatment of patients with locoregional recurrent breast cancer. ABSTRACT: Background: Accurate monitoring of skin surface temperatures is necessary to ensure treatment quality during superficial hyperthermia. A high-resolution thermal monitoring sheet (TMS) was developed to monitor the skin surface temperature distribution. The influence of the TMS on applicator performance was investigated, feasibility and ability to reliably monitor the temperature distribution were evaluated in a clinical study. Methods: Phantom experiments were performed to determine the influence of the TMS on power deposition patterns, applicator efficiency, and heat transfer of the water bolus for 434 and 915 MHz applicators. Clinical feasibility was evaluated in 10 women with locoregional recurrent breast cancer. Skin surface temperatures during consecutive treatments were monitored alternatingly with either standard Amsterdam UMC thermometry or TMS. Treatments were compared using (generalized) linear mixed models. Results: The TMS did not significantly affect power deposition patterns and applicator efficiency (1–2%), the reduced heat transfer of the water boluses (51–56%) could be compensated by adjusting the water bolus flow. Skin surface temperatures were monitored reliably, and no alteration of thermal toxicity was observed compared to standard Amsterdam UMC thermometry. Conclusion: Clinical application of the TMS is feasible. Power deposition patterns and applicator efficiency were not affected. Surface temperatures were monitored reliably.