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The Mysteries around the BCL-2 Family Member BOK

BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK...

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Autores principales: Shalaby, Raed, Flores-Romero, Hector, García-Sáez, Ana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762061/
https://www.ncbi.nlm.nih.gov/pubmed/33291826
http://dx.doi.org/10.3390/biom10121638
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author Shalaby, Raed
Flores-Romero, Hector
García-Sáez, Ana J.
author_facet Shalaby, Raed
Flores-Romero, Hector
García-Sáez, Ana J.
author_sort Shalaby, Raed
collection PubMed
description BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate, BOK has been associated with a plethora of non-apoptotic functions that makes this protein unpredictable when dictating cell fate. Here, we compile the current knowledge and open questions about this paradoxical protein with a special focus on its structural features as the key aspect to understand BOK biological functions.
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spelling pubmed-77620612020-12-26 The Mysteries around the BCL-2 Family Member BOK Shalaby, Raed Flores-Romero, Hector García-Sáez, Ana J. Biomolecules Review BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate, BOK has been associated with a plethora of non-apoptotic functions that makes this protein unpredictable when dictating cell fate. Here, we compile the current knowledge and open questions about this paradoxical protein with a special focus on its structural features as the key aspect to understand BOK biological functions. MDPI 2020-12-04 /pmc/articles/PMC7762061/ /pubmed/33291826 http://dx.doi.org/10.3390/biom10121638 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shalaby, Raed
Flores-Romero, Hector
García-Sáez, Ana J.
The Mysteries around the BCL-2 Family Member BOK
title The Mysteries around the BCL-2 Family Member BOK
title_full The Mysteries around the BCL-2 Family Member BOK
title_fullStr The Mysteries around the BCL-2 Family Member BOK
title_full_unstemmed The Mysteries around the BCL-2 Family Member BOK
title_short The Mysteries around the BCL-2 Family Member BOK
title_sort mysteries around the bcl-2 family member bok
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762061/
https://www.ncbi.nlm.nih.gov/pubmed/33291826
http://dx.doi.org/10.3390/biom10121638
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