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Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix

Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend...

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Autores principales: Kemenesi, Gábor, Zeghbib, Safia, Somogyi, Balázs A, Tóth, Gábor Endre, Bányai, Krisztián, Solymosi, Norbert, Szabo, Peter M, Szabó, István, Bálint, Ádám, Urbán, Péter, Herczeg, Róbert, Gyenesei, Attila, Nagy, Ágnes, Pereszlényi, Csaba István, Babinszky, Gergely Csaba, Dudás, Gábor, Terhes, Gabriella, Zöldi, Viktor, Lovas, Róbert, Tenczer, Szabolcs, Kornya, László, Jakab, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762115/
https://www.ncbi.nlm.nih.gov/pubmed/33291299
http://dx.doi.org/10.3390/v12121401
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author Kemenesi, Gábor
Zeghbib, Safia
Somogyi, Balázs A
Tóth, Gábor Endre
Bányai, Krisztián
Solymosi, Norbert
Szabo, Peter M
Szabó, István
Bálint, Ádám
Urbán, Péter
Herczeg, Róbert
Gyenesei, Attila
Nagy, Ágnes
Pereszlényi, Csaba István
Babinszky, Gergely Csaba
Dudás, Gábor
Terhes, Gabriella
Zöldi, Viktor
Lovas, Róbert
Tenczer, Szabolcs
Kornya, László
Jakab, Ferenc
author_facet Kemenesi, Gábor
Zeghbib, Safia
Somogyi, Balázs A
Tóth, Gábor Endre
Bányai, Krisztián
Solymosi, Norbert
Szabo, Peter M
Szabó, István
Bálint, Ádám
Urbán, Péter
Herczeg, Róbert
Gyenesei, Attila
Nagy, Ágnes
Pereszlényi, Csaba István
Babinszky, Gergely Csaba
Dudás, Gábor
Terhes, Gabriella
Zöldi, Viktor
Lovas, Róbert
Tenczer, Szabolcs
Kornya, László
Jakab, Ferenc
author_sort Kemenesi, Gábor
collection PubMed
description Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.
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spelling pubmed-77621152020-12-26 Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix Kemenesi, Gábor Zeghbib, Safia Somogyi, Balázs A Tóth, Gábor Endre Bányai, Krisztián Solymosi, Norbert Szabo, Peter M Szabó, István Bálint, Ádám Urbán, Péter Herczeg, Róbert Gyenesei, Attila Nagy, Ágnes Pereszlényi, Csaba István Babinszky, Gergely Csaba Dudás, Gábor Terhes, Gabriella Zöldi, Viktor Lovas, Róbert Tenczer, Szabolcs Kornya, László Jakab, Ferenc Viruses Article Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe. MDPI 2020-12-06 /pmc/articles/PMC7762115/ /pubmed/33291299 http://dx.doi.org/10.3390/v12121401 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kemenesi, Gábor
Zeghbib, Safia
Somogyi, Balázs A
Tóth, Gábor Endre
Bányai, Krisztián
Solymosi, Norbert
Szabo, Peter M
Szabó, István
Bálint, Ádám
Urbán, Péter
Herczeg, Róbert
Gyenesei, Attila
Nagy, Ágnes
Pereszlényi, Csaba István
Babinszky, Gergely Csaba
Dudás, Gábor
Terhes, Gabriella
Zöldi, Viktor
Lovas, Róbert
Tenczer, Szabolcs
Kornya, László
Jakab, Ferenc
Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title_full Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title_fullStr Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title_full_unstemmed Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title_short Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
title_sort multiple sars-cov-2 introductions shaped the early outbreak in central eastern europe: comparing hungarian data to a worldwide sequence data-matrix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762115/
https://www.ncbi.nlm.nih.gov/pubmed/33291299
http://dx.doi.org/10.3390/v12121401
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