Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity

SIMPLE SUMMARY: Cytotoxic T lymphocytes kill cancer or virally infected cells by exocytosis of lytic granules. This leads to perforin-mediated granzyme entry into the target cell, consequently killing the target cell. Granzymes and perforin are activated by cysteine cathepsins whose activity is regu...

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Detalles Bibliográficos
Autores principales: Prunk, Mateja, Perišić Nanut, Milica, Jakoš, Tanja, Sabotič, Jerica, Švajger, Urban, Kos, Janko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762138/
https://www.ncbi.nlm.nih.gov/pubmed/33291222
http://dx.doi.org/10.3390/cancers12123660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762138/
https://www.ncbi.nlm.nih.gov/pubmed/33291222
http://dx.doi.org/10.3390/cancers12123660

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