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Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both within the tumor and among individuals, which is closely related to the HCC surveillance, diagnosis, prognosis, and treatment resp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762241/ https://www.ncbi.nlm.nih.gov/pubmed/33297335 http://dx.doi.org/10.3390/biomedicines8120576 |
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author | Pan, Yasi Chen, Huarong Yu, Jun |
author_facet | Pan, Yasi Chen, Huarong Yu, Jun |
author_sort | Pan, Yasi |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both within the tumor and among individuals, which is closely related to the HCC surveillance, diagnosis, prognosis, and treatment response. With the advances of next-generation sequencing, the genomic landscape of HCC has been identified which vastly improves our understanding of genetic and epigenetic changes and their interaction during HCC development. In particular, gene mutations, epigenetic modifications, aberrant expression of coding and non-coding RNAs have been extensively explored and many of them are considered as biomarkers for HCC. Most recently, the gut microbiome has been proposed as potential non-invasive biomarkers for HCC diagnosis. In this review, we summarize the current development of HCC biomarkers studies and provide insights on further steps towards precision medicine of HCC. |
format | Online Article Text |
id | pubmed-7762241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77622412020-12-26 Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives Pan, Yasi Chen, Huarong Yu, Jun Biomedicines Review Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both within the tumor and among individuals, which is closely related to the HCC surveillance, diagnosis, prognosis, and treatment response. With the advances of next-generation sequencing, the genomic landscape of HCC has been identified which vastly improves our understanding of genetic and epigenetic changes and their interaction during HCC development. In particular, gene mutations, epigenetic modifications, aberrant expression of coding and non-coding RNAs have been extensively explored and many of them are considered as biomarkers for HCC. Most recently, the gut microbiome has been proposed as potential non-invasive biomarkers for HCC diagnosis. In this review, we summarize the current development of HCC biomarkers studies and provide insights on further steps towards precision medicine of HCC. MDPI 2020-12-07 /pmc/articles/PMC7762241/ /pubmed/33297335 http://dx.doi.org/10.3390/biomedicines8120576 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pan, Yasi Chen, Huarong Yu, Jun Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title | Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title_full | Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title_fullStr | Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title_full_unstemmed | Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title_short | Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives |
title_sort | biomarkers in hepatocellular carcinoma: current status and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762241/ https://www.ncbi.nlm.nih.gov/pubmed/33297335 http://dx.doi.org/10.3390/biomedicines8120576 |
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