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The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor
We studied how aging affects the ability of Drosophila melanogaster to tolerate various types of stress factors. Data were obtained on the resistance of D. melanogaster to oxidative and genotoxic (separately paraquat, Fe(3+), Cu(2+), and Zn(2+) ions), proteotoxic (hyperthermia, Cd(2+) ions), and osm...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762242/ https://www.ncbi.nlm.nih.gov/pubmed/33297320 http://dx.doi.org/10.3390/antiox9121239 |
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author | Belyi, Alexei A. Alekseev, Alexey A. Fedintsev, Alexander Y. Balybin, Stepan N. Proshkina, Ekaterina N. Shaposhnikov, Mikhail V. Moskalev, Alexey A. |
author_facet | Belyi, Alexei A. Alekseev, Alexey A. Fedintsev, Alexander Y. Balybin, Stepan N. Proshkina, Ekaterina N. Shaposhnikov, Mikhail V. Moskalev, Alexey A. |
author_sort | Belyi, Alexei A. |
collection | PubMed |
description | We studied how aging affects the ability of Drosophila melanogaster to tolerate various types of stress factors. Data were obtained on the resistance of D. melanogaster to oxidative and genotoxic (separately paraquat, Fe(3+), Cu(2+), and Zn(2+) ions), proteotoxic (hyperthermia, Cd(2+) ions), and osmotic (NaCl) stresses, starvation, and infection with the pathological Beauveria bassiana fungus at different ages. In all cases, we observed a strong negative correlation between age and stress tolerance. The largest change in the age-dependent decline in survival occurred under oxidative and osmotic stress. In most experiments, we observed that young Drosophila females have higher stress resistance than males. We checked whether it is possible to accurately assess the biological age of D. melanogaster based on an assessment of stress tolerance. We have proposed a new approach for assessing a biological age of D. melanogaster using a two-parameter survival curve model. For the model, we used an algorithm that evaluated the quality of age prediction for different age and gender groups. The best predictions were obtained for females who were exposed to CdCl(2) and ZnCl(2) with an average error of 0.32 days and 0.36 days, respectively. For males, the best results were observed for paraquat and NaCl with an average error of 0.61 and 0.68 days, respectively. The average accuracy for all stresses in our model was 1.73 days. |
format | Online Article Text |
id | pubmed-7762242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77622422020-12-26 The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor Belyi, Alexei A. Alekseev, Alexey A. Fedintsev, Alexander Y. Balybin, Stepan N. Proshkina, Ekaterina N. Shaposhnikov, Mikhail V. Moskalev, Alexey A. Antioxidants (Basel) Article We studied how aging affects the ability of Drosophila melanogaster to tolerate various types of stress factors. Data were obtained on the resistance of D. melanogaster to oxidative and genotoxic (separately paraquat, Fe(3+), Cu(2+), and Zn(2+) ions), proteotoxic (hyperthermia, Cd(2+) ions), and osmotic (NaCl) stresses, starvation, and infection with the pathological Beauveria bassiana fungus at different ages. In all cases, we observed a strong negative correlation between age and stress tolerance. The largest change in the age-dependent decline in survival occurred under oxidative and osmotic stress. In most experiments, we observed that young Drosophila females have higher stress resistance than males. We checked whether it is possible to accurately assess the biological age of D. melanogaster based on an assessment of stress tolerance. We have proposed a new approach for assessing a biological age of D. melanogaster using a two-parameter survival curve model. For the model, we used an algorithm that evaluated the quality of age prediction for different age and gender groups. The best predictions were obtained for females who were exposed to CdCl(2) and ZnCl(2) with an average error of 0.32 days and 0.36 days, respectively. For males, the best results were observed for paraquat and NaCl with an average error of 0.61 and 0.68 days, respectively. The average accuracy for all stresses in our model was 1.73 days. MDPI 2020-12-07 /pmc/articles/PMC7762242/ /pubmed/33297320 http://dx.doi.org/10.3390/antiox9121239 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Belyi, Alexei A. Alekseev, Alexey A. Fedintsev, Alexander Y. Balybin, Stepan N. Proshkina, Ekaterina N. Shaposhnikov, Mikhail V. Moskalev, Alexey A. The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title | The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title_full | The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title_fullStr | The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title_full_unstemmed | The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title_short | The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor |
title_sort | resistance of drosophila melanogaster to oxidative, genotoxic, proteotoxic, osmotic stress, infection, and starvation depends on age according to the stress factor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762242/ https://www.ncbi.nlm.nih.gov/pubmed/33297320 http://dx.doi.org/10.3390/antiox9121239 |
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