Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, thro...

Descripción completa

Detalles Bibliográficos
Autores principales: Romeo, Maria Anele, Santarelli, Roberta, Gilardini Montani, Maria Saveria, Gonnella, Roberta, Benedetti, Rossella, Faggioni, Alberto, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762304/
https://www.ncbi.nlm.nih.gov/pubmed/33297368
http://dx.doi.org/10.3390/cells9122624
_version_ 1783627773521166336
author Romeo, Maria Anele
Santarelli, Roberta
Gilardini Montani, Maria Saveria
Gonnella, Roberta
Benedetti, Rossella
Faggioni, Alberto
Cirone, Mara
author_facet Romeo, Maria Anele
Santarelli, Roberta
Gilardini Montani, Maria Saveria
Gonnella, Roberta
Benedetti, Rossella
Faggioni, Alberto
Cirone, Mara
author_sort Romeo, Maria Anele
collection PubMed
description Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer’s disease to cancer.
format Online
Article
Text
id pubmed-7762304
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77623042020-12-26 Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV Romeo, Maria Anele Santarelli, Roberta Gilardini Montani, Maria Saveria Gonnella, Roberta Benedetti, Rossella Faggioni, Alberto Cirone, Mara Cells Commentary Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer’s disease to cancer. MDPI 2020-12-07 /pmc/articles/PMC7762304/ /pubmed/33297368 http://dx.doi.org/10.3390/cells9122624 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Romeo, Maria Anele
Santarelli, Roberta
Gilardini Montani, Maria Saveria
Gonnella, Roberta
Benedetti, Rossella
Faggioni, Alberto
Cirone, Mara
Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title_full Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title_fullStr Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title_full_unstemmed Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title_short Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
title_sort viral infection and autophagy dysregulation: the case of hhv-6, ebv and kshv
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762304/
https://www.ncbi.nlm.nih.gov/pubmed/33297368
http://dx.doi.org/10.3390/cells9122624
work_keys_str_mv AT romeomariaanele viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT santarelliroberta viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT gilardinimontanimariasaveria viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT gonnellaroberta viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT benedettirossella viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT faggionialberto viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv
AT cironemara viralinfectionandautophagydysregulationthecaseofhhv6ebvandkshv

Ejemplares similares