Cargando…

Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer

As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yan, He, Ziqin, Ye, Jiazhou, Liu, Ziyu, She, Xiaomin, Gao, Xing, Liang, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762435/ https://www.ncbi.nlm.nih.gov/pubmed/33376351 http://dx.doi.org/10.2147/OTT.S278013

Ejemplares similares

Eukaryotic Initiation Factor 4A-3: A Review of Its Physiological Role and Involvement in Oncogenesis
por: Ye, Jiazhou, et al.
Publicado: (2021)

RNA-Binding Motif Protein 38 as a Potential Biomarker and Therapeutic Target in Cancer
por: She, Xiaomin, et al.
Publicado: (2020)

RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5
por: Gao, Xing, et al.
Publicado: (2023)

Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma
por: Chen, Mei, et al.
Publicado: (2020)

Integrative Analysis Reveals the Potential Role and Prognostic Value of GOLM1 in Hepatocellular Carcinoma
por: Lin, Yan, et al.
Publicado: (2022)

Progress of research on molecular targeted therapies for colorectal cancer
por: Huang, Shilin, et al.
Publicado: (2023)

A twenty gene-based gene set variation score reflects the pathological progression from cirrhosis to hepatocellular carcinoma
por: Lin, Yan, et al.
Publicado: (2019)

Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling
por: Zhang, Xiaochao, et al.
Publicado: (2018)

Construction of a Comprehensive Multiomics Map of Hepatocellular Carcinoma and Screening of Possible Driver Genes
por: Liu, Ziyu, et al.
Publicado: (2020)

LNRRIL6, a novel long noncoding RNA, protects colorectal cancer cells by activating the IL‐6–STAT3 pathway
por: Wang, Jiaxing, et al.
Publicado: (2019)

The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma
por: Ye, Hua, et al.
Publicado: (2022)

Effective Treatment of Low-Grade Myofibroblastic Sarcoma with Apatinib: A Case Report and Literature Review
por: Lin, Yan, et al.
Publicado: (2022)

Active Components with Inhibitory Activities on IFN-γ/STAT1 and IL-6/STAT3 Signaling Pathways from Caulis Trachelospermi
por: Liu, Xiao-Ting, et al.
Publicado: (2014)

IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling
por: Chen, Cheng, et al.
Publicado: (2017)

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway
por: Wang, Lin, et al.
Publicado: (2009)

Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β
por: Yoo, Jihye, et al.
Publicado: (2022)

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis
por: von Essen, Marina R., et al.
Publicado: (2019)

Role of IL-6/JAK/STAT pathway in inducing vascular insulin resistance
por: Balakrishnan, Aswath, et al.
Publicado: (2014)

Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms
por: Čokić, Vladan P., et al.
Publicado: (2015)

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
por: Dritsoula, Athina, et al.
Publicado: (2022)

The role of IL-6/JAK2/STAT3 signaling pathway in cancers
por: Huang, Bei, et al.
Publicado: (2022)

Analysis of the Influence of IL-6 and the Activation of the Jak/Stat3 Pathway in Fibromyalgia
por: Marino, Ylenia, et al.
Publicado: (2023)

IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
por: Gu, Fang-Ming, et al.
Publicado: (2011)

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
por: Liang, Tongzhou, et al.
Publicado: (2021)

IL‐37 inhibits invasion and metastasis in non‐small cell lung cancer by suppressing the IL‐6/STAT3 signaling pathway
por: Jiang, Mingfang, et al.
Publicado: (2018)

Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway
por: Ge, Jing, et al.
Publicado: (2020)

Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells
por: Fu, Cuiping, et al.
Publicado: (2019)

Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway
por: Xin, Yunchao, et al.
Publicado: (2021)

Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with STAT3
por: Wu, Aihua, et al.
Publicado: (2023)

IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway
por: Qin, Beibei, et al.
Publicado: (2015)

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
por: Ye, Xiaohong, et al.
Publicado: (2019)

UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling
por: Gao, Xuedi, et al.
Publicado: (2022)

Regulation of TRPM7 Function by IL-6 through the JAK2-STAT3 Signaling Pathway
por: Liu, Aifen, et al.
Publicado: (2016)

Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson’s Disease Model
por: Yang, Xueping, et al.
Publicado: (2022)

The Role of MRE11 in the IL-6/STAT3 Pathway of Lung Cancer Cells
por: Wu, Ching-Yuan, et al.
Publicado: (2022)

Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway
por: Cui, Can, et al.
Publicado: (2019)

IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma
por: Wu, Jian, et al.
Publicado: (2019)

circPTPN12 promotes the progression and sunitinib resistance of renal cancer via hnRNPM/IL-6/STAT3 pathway
por: Shou, Yi, et al.
Publicado: (2023)

E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells
por: Chen, Jiaoe, et al.
Publicado: (2018)

IL-6-STAT3 signaling and premature senescence
por: Kojima, Hirotada, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fp1t63m8m9hb45riapda6fal72