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Insight into the Role of Angiopoietins in Ageing-Associated Diseases

Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is ex...

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Autores principales: Hayashi, Shin-ichiro, Rakugi, Hiromi, Morishita, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762563/
https://www.ncbi.nlm.nih.gov/pubmed/33302426
http://dx.doi.org/10.3390/cells9122636
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author Hayashi, Shin-ichiro
Rakugi, Hiromi
Morishita, Ryuichi
author_facet Hayashi, Shin-ichiro
Rakugi, Hiromi
Morishita, Ryuichi
author_sort Hayashi, Shin-ichiro
collection PubMed
description Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs.
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spelling pubmed-77625632020-12-26 Insight into the Role of Angiopoietins in Ageing-Associated Diseases Hayashi, Shin-ichiro Rakugi, Hiromi Morishita, Ryuichi Cells Review Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs. MDPI 2020-12-08 /pmc/articles/PMC7762563/ /pubmed/33302426 http://dx.doi.org/10.3390/cells9122636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hayashi, Shin-ichiro
Rakugi, Hiromi
Morishita, Ryuichi
Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title_full Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title_fullStr Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title_full_unstemmed Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title_short Insight into the Role of Angiopoietins in Ageing-Associated Diseases
title_sort insight into the role of angiopoietins in ageing-associated diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762563/
https://www.ncbi.nlm.nih.gov/pubmed/33302426
http://dx.doi.org/10.3390/cells9122636
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