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Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells

Cervical cancer is considered to be one of the most serious malignant tumors in women. Natural compounds have been considered as important sources in the search for new anticancer agents. Polygonum chinense (PC) has been used as herbal medicine and Chinese cool tea. By activity-guided of the extract...

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Autores principales: Chen, Wei, Shen, XianMin, Ma, Li, Chen, Rong, Yuan, Qin, Zheng, YunFeng, Li, CunYu, Peng, GuoPing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762659/
https://www.ncbi.nlm.nih.gov/pubmed/33381593
http://dx.doi.org/10.1155/2020/8868508
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author Chen, Wei
Shen, XianMin
Ma, Li
Chen, Rong
Yuan, Qin
Zheng, YunFeng
Li, CunYu
Peng, GuoPing
author_facet Chen, Wei
Shen, XianMin
Ma, Li
Chen, Rong
Yuan, Qin
Zheng, YunFeng
Li, CunYu
Peng, GuoPing
author_sort Chen, Wei
collection PubMed
description Cervical cancer is considered to be one of the most serious malignant tumors in women. Natural compounds have been considered as important sources in the search for new anticancer agents. Polygonum chinense (PC) has been used as herbal medicine and Chinese cool tea. By activity-guided of the extracts from PC, PC(water) shows good growth inhibition on SiHa cell, then by chromatographic analysis (HPLC and HPLC-MS/MS), we found twelve components, seven were phenolic compounds (PHE), two PHE named ellagic acid and corilagin were found to show strong growth inhibition effects in SiHa cell dose-dependently, while the seven phenolic compounds showed low inhibition on the common human HcerEpic cell. Further research found ellagic acid and corilagin induced G2 phase cell cycle arrest by upregulating levels of P53, Bcl-2, caspase 3, and caspase 9, while the Bax was reduced. These results suggested that PHE from PC might have potential anticancer effects against SiHa cells by acting through the apoptosis pathway, PHE from PC might have the potential to be used as a nutraceutical for the prevention and treatment of ovarian cancer.
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spelling pubmed-77626592020-12-29 Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells Chen, Wei Shen, XianMin Ma, Li Chen, Rong Yuan, Qin Zheng, YunFeng Li, CunYu Peng, GuoPing Biomed Res Int Research Article Cervical cancer is considered to be one of the most serious malignant tumors in women. Natural compounds have been considered as important sources in the search for new anticancer agents. Polygonum chinense (PC) has been used as herbal medicine and Chinese cool tea. By activity-guided of the extracts from PC, PC(water) shows good growth inhibition on SiHa cell, then by chromatographic analysis (HPLC and HPLC-MS/MS), we found twelve components, seven were phenolic compounds (PHE), two PHE named ellagic acid and corilagin were found to show strong growth inhibition effects in SiHa cell dose-dependently, while the seven phenolic compounds showed low inhibition on the common human HcerEpic cell. Further research found ellagic acid and corilagin induced G2 phase cell cycle arrest by upregulating levels of P53, Bcl-2, caspase 3, and caspase 9, while the Bax was reduced. These results suggested that PHE from PC might have potential anticancer effects against SiHa cells by acting through the apoptosis pathway, PHE from PC might have the potential to be used as a nutraceutical for the prevention and treatment of ovarian cancer. Hindawi 2020-12-18 /pmc/articles/PMC7762659/ /pubmed/33381593 http://dx.doi.org/10.1155/2020/8868508 Text en Copyright © 2020 Wei Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Wei
Shen, XianMin
Ma, Li
Chen, Rong
Yuan, Qin
Zheng, YunFeng
Li, CunYu
Peng, GuoPing
Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title_full Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title_fullStr Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title_full_unstemmed Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title_short Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
title_sort phenolic compounds from polygonum chinense induce growth inhibition and apoptosis of cervical cancer siha cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762659/
https://www.ncbi.nlm.nih.gov/pubmed/33381593
http://dx.doi.org/10.1155/2020/8868508
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