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Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population

BACKGROUND: It is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19. OBJECTIVES: This observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel d...

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Autores principales: Maconi, Giovanni, Bosetti, Cristina, De Monti, Alberta, Boyapati, Ray Kiran, Shelton, Edward, Piazza, Nicole, Carvalhas Gabrielli, Anna Maria, Lenti, Marco Vincenzo, Bezzio, Cristina, Ricci, Chiara, Greco, Salvatore, Romeo, Samanta, Giangregorio, Francesco, Gridavilla, Daniele, Tagliani, Fabio, Massari, Alessandro, Pastorelli, Luca, Di Sabatino, Antonio, Saibeni, Simone, Alicante, Saverio, Ferretti, Francesca, Rizzardini, Giuliano, Galli, Massimo, Ardizzone, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762705/
https://www.ncbi.nlm.nih.gov/pubmed/33483259
http://dx.doi.org/10.1016/j.dld.2020.12.013
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author Maconi, Giovanni
Bosetti, Cristina
De Monti, Alberta
Boyapati, Ray Kiran
Shelton, Edward
Piazza, Nicole
Carvalhas Gabrielli, Anna Maria
Lenti, Marco Vincenzo
Bezzio, Cristina
Ricci, Chiara
Greco, Salvatore
Romeo, Samanta
Giangregorio, Francesco
Gridavilla, Daniele
Tagliani, Fabio
Massari, Alessandro
Pastorelli, Luca
Di Sabatino, Antonio
Saibeni, Simone
Alicante, Saverio
Ferretti, Francesca
Rizzardini, Giuliano
Galli, Massimo
Ardizzone, Sandro
author_facet Maconi, Giovanni
Bosetti, Cristina
De Monti, Alberta
Boyapati, Ray Kiran
Shelton, Edward
Piazza, Nicole
Carvalhas Gabrielli, Anna Maria
Lenti, Marco Vincenzo
Bezzio, Cristina
Ricci, Chiara
Greco, Salvatore
Romeo, Samanta
Giangregorio, Francesco
Gridavilla, Daniele
Tagliani, Fabio
Massari, Alessandro
Pastorelli, Luca
Di Sabatino, Antonio
Saibeni, Simone
Alicante, Saverio
Ferretti, Francesca
Rizzardini, Giuliano
Galli, Massimo
Ardizzone, Sandro
author_sort Maconi, Giovanni
collection PubMed
description BACKGROUND: It is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19. OBJECTIVES: This observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel disorders. METHODS: This multicentre study, included 2733 outpatients (1397 IBD patients and 1336 controls), from eight major gastrointestinal centres in Lombardy, Italy. Patients were invited to complete a web-based questionnaire regarding demographic, historical and clinical features over the previous 6 weeks. The prevalence of COVID-19 symptoms, diagnosis and hospitalization for COVID-19 was assessed. RESULTS: 1810 patients (64%) responded to the questionnaire (941 IBD patients and 869 controls). IBD patients were significantly younger and of male sex than controls. NSAID use and smoking were more frequent in controls. IBD patients were more likely treated with vitamin-D and vaccinated for influenza. Highly probable COVID-19 on the basis of symptoms and signs was less frequent in the IBD group (3.8% vs 6.3%; OR:0.45, 95%CI:0.28–0.75). IBD patients had a lower rate of nasopharyngeal swab-PCR confirmed diagnosis (0.2% vs 1.2%; OR:0.14, 95%CI:0.03–0.67). There was no difference in hospitalization between the groups (0.1% vs 0.6%; OR:0.14, 95%CI:0.02–1.17). CONCLUSION: IBD patients do not have an increased risk of COVID-19 specific symptoms or more severe disease compared with a control group of gastroenterology patients.
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spelling pubmed-77627052020-12-28 Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population Maconi, Giovanni Bosetti, Cristina De Monti, Alberta Boyapati, Ray Kiran Shelton, Edward Piazza, Nicole Carvalhas Gabrielli, Anna Maria Lenti, Marco Vincenzo Bezzio, Cristina Ricci, Chiara Greco, Salvatore Romeo, Samanta Giangregorio, Francesco Gridavilla, Daniele Tagliani, Fabio Massari, Alessandro Pastorelli, Luca Di Sabatino, Antonio Saibeni, Simone Alicante, Saverio Ferretti, Francesca Rizzardini, Giuliano Galli, Massimo Ardizzone, Sandro Dig Liver Dis Alimentary Tract BACKGROUND: It is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19. OBJECTIVES: This observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel disorders. METHODS: This multicentre study, included 2733 outpatients (1397 IBD patients and 1336 controls), from eight major gastrointestinal centres in Lombardy, Italy. Patients were invited to complete a web-based questionnaire regarding demographic, historical and clinical features over the previous 6 weeks. The prevalence of COVID-19 symptoms, diagnosis and hospitalization for COVID-19 was assessed. RESULTS: 1810 patients (64%) responded to the questionnaire (941 IBD patients and 869 controls). IBD patients were significantly younger and of male sex than controls. NSAID use and smoking were more frequent in controls. IBD patients were more likely treated with vitamin-D and vaccinated for influenza. Highly probable COVID-19 on the basis of symptoms and signs was less frequent in the IBD group (3.8% vs 6.3%; OR:0.45, 95%CI:0.28–0.75). IBD patients had a lower rate of nasopharyngeal swab-PCR confirmed diagnosis (0.2% vs 1.2%; OR:0.14, 95%CI:0.03–0.67). There was no difference in hospitalization between the groups (0.1% vs 0.6%; OR:0.14, 95%CI:0.02–1.17). CONCLUSION: IBD patients do not have an increased risk of COVID-19 specific symptoms or more severe disease compared with a control group of gastroenterology patients. Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. 2021-03 2020-12-26 /pmc/articles/PMC7762705/ /pubmed/33483259 http://dx.doi.org/10.1016/j.dld.2020.12.013 Text en © 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Alimentary Tract
Maconi, Giovanni
Bosetti, Cristina
De Monti, Alberta
Boyapati, Ray Kiran
Shelton, Edward
Piazza, Nicole
Carvalhas Gabrielli, Anna Maria
Lenti, Marco Vincenzo
Bezzio, Cristina
Ricci, Chiara
Greco, Salvatore
Romeo, Samanta
Giangregorio, Francesco
Gridavilla, Daniele
Tagliani, Fabio
Massari, Alessandro
Pastorelli, Luca
Di Sabatino, Antonio
Saibeni, Simone
Alicante, Saverio
Ferretti, Francesca
Rizzardini, Giuliano
Galli, Massimo
Ardizzone, Sandro
Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title_full Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title_fullStr Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title_full_unstemmed Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title_short Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
title_sort risk of covid 19 in patients with inflammatory bowel diseases compared to a control population
topic Alimentary Tract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762705/
https://www.ncbi.nlm.nih.gov/pubmed/33483259
http://dx.doi.org/10.1016/j.dld.2020.12.013
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