m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that HNF3γ expression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival. Mor...

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Detalles Bibliográficos
Autores principales: Zhou, Tengfei, Li, Shichao, Xiang, Daimin, Liu, Junyu, Sun, Wen, Cui, Xiuliang, Ning, Beifang, Li, Xiao, Cheng, Zhuo, Jiang, Weiqi, Zhang, Cheng, Liang, Xijun, Li, Liang, Cheng, Xin, Hui, Liu, Wang, Hongyang, Ding, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762754/
https://www.ncbi.nlm.nih.gov/pubmed/33361765
http://dx.doi.org/10.1038/s41392-020-00299-0

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