Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores

Recent CYP2D6 phenotype standardization efforts by CYP2D6 activity score (AS) are based on limited pharmacokinetic (PK) and pharmacodynamic (PD) data. Using data from two independent clinical trials of metoprolol, we compared metoprolol PK and PD across CYP2D6 AS with the goal of determining whether...

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Detalles Bibliográficos
Autores principales: Thomas, Cameron D., Mosley, Scott A., Kim, Sarah, Lingineni, Karthik, El Rouby, Nihal, Langaee, Taimour Y., Gong, Yan, Wang, Danxin, Schmidt, Siegfried O., Binkley, Philip F., Estores, David S., Feng, Kairui, Kim, Hyewon, Kinjo, Minori, Li, Zhichuan, Fang, Lanyan, Chapman, Arlene B., Cooper-DeHoff, Rhonda M., Gums, John G., Hamadeh, Issam S., Zhao, Liang, Schmidt, Stephan, Frye, Reginald F., Johnson, Julie A., Cavallari, Larisa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762806/
https://www.ncbi.nlm.nih.gov/pubmed/33067866
http://dx.doi.org/10.1002/psp4.12563

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