Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage

OBJECTIVE: The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage. DESIGN: Secretomes from wild-type and Adam15(−/−) chondrocytes were compared by label-free quan...

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Detalles Bibliográficos
Autores principales: Yang, C.Y., Chanalaris, A., Bonelli, S., McClurg, O., Hiles, G. Lorenzatti, Cates, A.L., Zarebska, J. Miotla, Vincent, T.L., Day, M.L., Müller, S.A., Lichtenthaler, S.F., Nagase, H., Scilabra, S.D., Troeberg, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762825/
https://www.ncbi.nlm.nih.gov/pubmed/33381768
http://dx.doi.org/10.1016/j.ocarto.2020.100128

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