Cargando…

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fahrig-Kamarauskait≑, Jūrate˙, Würth-Roderer, Kathrin, Thorbjørnsrud, Helen V., Mailand, Susanne, Krengel, Ute, Kast, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762937/ https://www.ncbi.nlm.nih.gov/pubmed/33453995 http://dx.doi.org/10.1074/jbc.RA120.014924

Ejemplares similares

What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study
por: Thorbjørnsrud, Helen V., et al.
Publicado: (2023)

Novel exported fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: Shikimate pathway enzymes teamed up in no man's land
por: Stocker, Christian, et al.
Publicado: (2023)

Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved
por: Krengel, Ute, et al.
Publicado: (2006)

Quantum chemical modeling of the reaction path of chorismate mutase based on the experimental substrate/product complex
por: Burschowsky, Daniel, et al.
Publicado: (2017)

The importance of chorismate mutase in the biocontrol potential of Trichoderma parareesei
por: Pérez, Esclaudys, et al.
Publicado: (2015)

Chorismate mutase peptide antibody enables specific detection of Acanthamoeba
por: Lee, Hae-Ahm, et al.
Publicado: (2021)

Putative Bifunctional Chorismate Mutase/Prephenate Dehydratase Contributes to the Virulence of Acidovorax citrulli
por: Kim, Minyoung, et al.
Publicado: (2020)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)
por: Ahangar, Mohd Syed, et al.
Publicado: (2018)

InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
por: Vögeli, Bastian, et al.
Publicado: (2018)

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
por: Chenge, Jude T., et al.
Publicado: (2017)

Horizontal gene transfer of acetyltransferases, invertases and chorismate mutases from different bacteria to diverse recipients
por: Noon, Jason B., et al.
Publicado: (2016)

Evaluating the Diagnostic Potential of Chorismate Mutase Poly-Clonal Peptide Antibody for the Acanthamoeba Keratitis in an Animal Model
por: Kim, Min-Jeong, et al.
Publicado: (2023)

Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapy
por: Jeong, Hyein, et al.
Publicado: (2022)

A Secreted Chorismate Mutase from Xanthomonas arboricola pv. juglandis Attenuates Virulence and Walnut Blight Symptoms
por: Assis, Renata de A. B., et al.
Publicado: (2021)

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM
por: Drees, Steffen Lorenz, et al.
Publicado: (2016)

The emerging periplasm-localized subclass of AroQ chorismate mutases, exemplified by those from Salmonella typhimurium and Pseudomonas aeruginosa
por: Calhoun, David H, et al.
Publicado: (2001)

Over-Expression of Chorismate Mutase Enhances the Accumulation of Salicylic Acid, Lignin, and Antioxidants in Response to the White-Backed Planthopper in Rice Plants
por: Jan, Rahmatullah, et al.
Publicado: (2021)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
por: Singleton, Rachelle S., et al.
Publicado: (2011)

Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44
por: Ariza, Antonio, et al.
Publicado: (2011)

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex
por: Vorontsov, Ivan I., et al.
Publicado: (2011)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities
por: Bloemink, Marieke J., et al.
Publicado: (2011)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
por: Szeto, Mindy D., et al.
Publicado: (2011)

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
por: Ishizuka, Tomoko, et al.
Publicado: (2010)

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity
por: Schwendener, Sybille, et al.
Publicado: (2010)

Dynamic Mechanism of Proton Transfer in Mannitol 2-Dehydrogenase from Pseudomonas fluorescens: MOBILE GLU(292) CONTROLS PROTON RELAY THROUGH A WATER CHANNEL THAT CONNECTS THE ACTIVE SITE WITH BULK SOLVENT
por: Klimacek, Mario, et al.
Publicado: (2012)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex
por: Jin, Zhinan, et al.
Publicado: (2012)

Kinetic Characterization of Single Strand Break Ligation in Duplex DNA by T4 DNA Ligase
por: Lohman, Gregory J. S., et al.
Publicado: (2011)

Cellulases Dig Deep: IN SITU OBSERVATION OF THE MESOSCOPIC STRUCTURAL DYNAMICS OF ENZYMATIC CELLULOSE DEGRADATION
por: Bubner, Patricia, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7o5mqtu82sdae1gm1kvqlg2h6e