Cargando…

Visualizing, quantifying, and manipulating mitochondrial DNA in vivo

Mitochondrial DNA (mtDNA) encodes proteins and RNAs that support the functions of mitochondria and thereby numerous physiological processes. Mutations of mtDNA can cause mitochondrial diseases and are implicated in aging. The mtDNA within cells is organized into nucleoids within the mitochondrial ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prole, David L., Chinnery, Patrick F., Jones, Nick S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	JBC Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762947/ https://www.ncbi.nlm.nih.gov/pubmed/33454000 http://dx.doi.org/10.1074/jbc.REV120.015101

Ejemplares similares

Structure, mechanism, and regulation of mitochondrial DNA transcription initiation
por: Basu, Urmimala, et al.
Publicado: (2021)

Mitochondrial metabolism regulates macrophage biology
por: Wang, Yafang, et al.
Publicado: (2021)

Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications
por: Lechado Terradas, Anna, et al.
Publicado: (2021)

Structural biology of ex vivo mammalian prions
por: Artikis, Efrosini, et al.
Publicado: (2022)

Pathways and disease-causing alterations in visual chromophore production for vertebrate vision
por: Kiser, Philip D., et al.
Publicado: (2020)

Mitochondrial protein translocation machinery: From TOM structural biogenesis to functional regulation
por: Sayyed, Ulfat Mohd. Hanif, et al.
Publicado: (2022)

Role of condensates in modulating DNA repair pathways and its implication for chemoresistance
por: Dall’Agnese, Giuseppe, et al.
Publicado: (2023)

Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress
por: Chalifoux, Olivia, et al.
Publicado: (2023)

The mitochondrial amidoxime reducing component—from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target
por: Struwe, Michel A., et al.
Publicado: (2023)

Beyond the double helix: DNA structural diversity and the PDB
por: Neidle, Stephen
Publicado: (2021)

Probing steps in DNA transcription using single-molecule methods
por: Lee, Chun-Ying, et al.
Publicado: (2021)

A half century of exploring DNA excision repair in chromatin
por: Smerdon, Michael J., et al.
Publicado: (2023)

Fueling genome maintenance: On the versatile roles of NAD(+) in preserving DNA integrity
por: Ruszkiewicz, Joanna A., et al.
Publicado: (2022)

Bacterial iron detoxification at the molecular level
por: Bradley, Justin M., et al.
Publicado: (2020)

Evolution of standardization and dissemination of cryo-EM structures and data jointly by the community, PDB, and EMDB
por: Chiu, Wah, et al.
Publicado: (2021)

New strategies for targeting kinase networks in cancer
por: Yesilkanal, Ali E., et al.
Publicado: (2021)

The interplay of 3D genome organization with UV-induced DNA damage and repair
por: Akköse, Ümit, et al.
Publicado: (2023)

Seeing the PDB
por: Richardson, Jane S., et al.
Publicado: (2021)

Linking molecular evolution to molecular grafting
por: Wang, Conan K., et al.
Publicado: (2021)

Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases
por: Pratt, Matthew R., et al.
Publicado: (2023)

Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
por: Mabanglo, Mark F., et al.
Publicado: (2022)

Challenges in sample preparation and structure determination of amyloids by cryo-EM
por: Zielinski, Mara, et al.
Publicado: (2021)

Major tail proteins of bacteriophages of the order Caudovirales
por: Zinke, Maximilian, et al.
Publicado: (2021)

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria
por: Horne, Jim E., et al.
Publicado: (2020)

Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection
por: Shen, Qingtang, et al.
Publicado: (2021)

Structural basis for dysregulation of aminolevulinic acid synthase in human disease
por: Taylor, Jessica L., et al.
Publicado: (2022)

The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments
por: Cole, Gregory B., et al.
Publicado: (2020)

Next-generation sequencing: A new avenue to understand viral RNA–protein interactions
por: Zhou, Yiyang, et al.
Publicado: (2022)

Biochemical and structural basis of sialic acid utilization by gut microbes
por: Bell, Andrew, et al.
Publicado: (2023)

The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
por: Jackson, Jacob T., et al.
Publicado: (2021)

Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration
por: Dudás, Erika F., et al.
Publicado: (2021)

Antisense technology: A review
por: Crooke, Stanley T., et al.
Publicado: (2021)

Limb blastema formation: How much do we know at a genetic and epigenetic level?
por: Min, Sangwon, et al.
Publicado: (2022)

The universe of galectin-binding partners and their functions in health and disease
por: Troncoso, María F., et al.
Publicado: (2023)

Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition
por: East, Michael P., et al.
Publicado: (2021)

50 Years of structural immunology
por: Wilson, Ian A., et al.
Publicado: (2021)

Circadian clock, carcinogenesis, chronochemotherapy connections
por: Yang, Yanyan, et al.
Publicado: (2021)

The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes
por: Frkic, Rebecca L., et al.
Publicado: (2021)

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
por: Rutledge, Benjamin S., et al.
Publicado: (2022)

Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity
por: Ercig, Bogac, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d0epqkotm5grtue2ru4h6olr45