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Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism

Highly engineered phytases, which sequentially hydrolyze the hexakisphosphate ester of inositol known as phytic acid, are routinely added to the feeds of monogastric animals to improve phosphate bioavailability. New phytases are sought as starting points to further optimize the rate and extent of de...

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Detalles Bibliográficos
Autores principales:	Acquistapace, Isabella M., Zi¸etek, Monika A., Li, Arthur W. H., Salmon, Melissa, Kühn, Imke, Bedford, Mike R., Brearley, Charles A., Hemmings, Andrew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762957/ https://www.ncbi.nlm.nih.gov/pubmed/33454010 http://dx.doi.org/10.1074/jbc.RA120.015925

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