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Many Different LINE-1 Retroelements Are Activated in Bladder Cancer

Human genomes contain about 100,000 LINE-1 (L1) retroelements, of which more than 100 are intact. L1s are normally tightly controlled by epigenetic mechanisms, which often fail in cancer. In bladder urothelial carcinoma (UC), particularly, L1s become DNA-hypomethylated, expressed and contribute to g...

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Detalles Bibliográficos
Autores principales:	Whongsiri, Patcharawalai, Goering, Wolfgang, Lautwein, Tobias, Hader, Christiane, Niegisch, Günter, Köhrer, Karl, Hoffmann, Michèle J., Schulz, Wolfgang A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763009/ https://www.ncbi.nlm.nih.gov/pubmed/33322422 http://dx.doi.org/10.3390/ijms21249433

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