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Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-d...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763092/ https://www.ncbi.nlm.nih.gov/pubmed/33322198 http://dx.doi.org/10.3390/molecules25245906 |
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| author | Hassan, Sk. Sarif Ghosh, Shinjini Attrish, Diksha Choudhury, Pabitra Pal Aljabali, Alaa A. A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Uversky, Vladimir N. Seyran, Murat Pizzol, Damiano Adadi, Parise Soares, Antonio El-Aziz, Tarek Mohamed Abd Kandimalla, Ramesh Tambuwala, Murtaza M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ángel Chauhan, Gaurav Palu, Giorgio Brufsky, Adam M. |
| author_facet | Hassan, Sk. Sarif Ghosh, Shinjini Attrish, Diksha Choudhury, Pabitra Pal Aljabali, Alaa A. A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Uversky, Vladimir N. Seyran, Murat Pizzol, Damiano Adadi, Parise Soares, Antonio El-Aziz, Tarek Mohamed Abd Kandimalla, Ramesh Tambuwala, Murtaza M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ángel Chauhan, Gaurav Palu, Giorgio Brufsky, Adam M. |
| author_sort | Hassan, Sk. Sarif |
| collection | PubMed |
| description | Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. |
| format | Online Article Text |
| id | pubmed-7763092 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77630922020-12-27 Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features Hassan, Sk. Sarif Ghosh, Shinjini Attrish, Diksha Choudhury, Pabitra Pal Aljabali, Alaa A. A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Uversky, Vladimir N. Seyran, Murat Pizzol, Damiano Adadi, Parise Soares, Antonio El-Aziz, Tarek Mohamed Abd Kandimalla, Ramesh Tambuwala, Murtaza M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ángel Chauhan, Gaurav Palu, Giorgio Brufsky, Adam M. Molecules Article Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. MDPI 2020-12-13 /pmc/articles/PMC7763092/ /pubmed/33322198 http://dx.doi.org/10.3390/molecules25245906 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Hassan, Sk. Sarif Ghosh, Shinjini Attrish, Diksha Choudhury, Pabitra Pal Aljabali, Alaa A. A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Uversky, Vladimir N. Seyran, Murat Pizzol, Damiano Adadi, Parise Soares, Antonio El-Aziz, Tarek Mohamed Abd Kandimalla, Ramesh Tambuwala, Murtaza M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ángel Chauhan, Gaurav Palu, Giorgio Brufsky, Adam M. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_full | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_fullStr | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_full_unstemmed | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_short | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_sort | possible transmission flow of sars-cov-2 based on ace2 features |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763092/ https://www.ncbi.nlm.nih.gov/pubmed/33322198 http://dx.doi.org/10.3390/molecules25245906 |
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