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Future Perspectives in Small-Diameter Vascular Graft Engineering

The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal groups of non-communicable disorders worldwide. It h...

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Autores principales: Mallis, Panagiotis, Kostakis, Alkiviadis, Stavropoulos-Giokas, Catherine, Michalopoulos, Efstathios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763104/
https://www.ncbi.nlm.nih.gov/pubmed/33321830
http://dx.doi.org/10.3390/bioengineering7040160
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author Mallis, Panagiotis
Kostakis, Alkiviadis
Stavropoulos-Giokas, Catherine
Michalopoulos, Efstathios
author_facet Mallis, Panagiotis
Kostakis, Alkiviadis
Stavropoulos-Giokas, Catherine
Michalopoulos, Efstathios
author_sort Mallis, Panagiotis
collection PubMed
description The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal groups of non-communicable disorders worldwide. It has been estimated that in Europe, the healthcare cost for the administration of CVD is more than 169 billion €. Common manifestations involve the narrowing or occlusion of blood vessels. The replacement of damaged vessels with autologous grafts represents one of the applied therapeutic approaches in CVD. However, significant drawbacks are accompanying the above procedure; therefore, the exploration of alternative vessel sources must be performed. Engineered SDVGs can be produced through the utilization of non-degradable/degradable and naturally derived materials. Decellularized vessels represent also an alternative valuable source for the development of SDVGs. In this review, a great number of SDVG engineering approaches will be highlighted. Importantly, the state-of-the-art methodologies, which are currently employed, will be comprehensively presented. A discussion summarizing the key marks and the future perspectives of SDVG engineering will be included in this review. Taking into consideration the increased number of patients with CVD, SDVG engineering may assist significantly in cardiovascular reconstructive surgery and, therefore, the overall improvement of patients’ life.
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spelling pubmed-77631042020-12-27 Future Perspectives in Small-Diameter Vascular Graft Engineering Mallis, Panagiotis Kostakis, Alkiviadis Stavropoulos-Giokas, Catherine Michalopoulos, Efstathios Bioengineering (Basel) Review The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal groups of non-communicable disorders worldwide. It has been estimated that in Europe, the healthcare cost for the administration of CVD is more than 169 billion €. Common manifestations involve the narrowing or occlusion of blood vessels. The replacement of damaged vessels with autologous grafts represents one of the applied therapeutic approaches in CVD. However, significant drawbacks are accompanying the above procedure; therefore, the exploration of alternative vessel sources must be performed. Engineered SDVGs can be produced through the utilization of non-degradable/degradable and naturally derived materials. Decellularized vessels represent also an alternative valuable source for the development of SDVGs. In this review, a great number of SDVG engineering approaches will be highlighted. Importantly, the state-of-the-art methodologies, which are currently employed, will be comprehensively presented. A discussion summarizing the key marks and the future perspectives of SDVG engineering will be included in this review. Taking into consideration the increased number of patients with CVD, SDVG engineering may assist significantly in cardiovascular reconstructive surgery and, therefore, the overall improvement of patients’ life. MDPI 2020-12-10 /pmc/articles/PMC7763104/ /pubmed/33321830 http://dx.doi.org/10.3390/bioengineering7040160 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mallis, Panagiotis
Kostakis, Alkiviadis
Stavropoulos-Giokas, Catherine
Michalopoulos, Efstathios
Future Perspectives in Small-Diameter Vascular Graft Engineering
title Future Perspectives in Small-Diameter Vascular Graft Engineering
title_full Future Perspectives in Small-Diameter Vascular Graft Engineering
title_fullStr Future Perspectives in Small-Diameter Vascular Graft Engineering
title_full_unstemmed Future Perspectives in Small-Diameter Vascular Graft Engineering
title_short Future Perspectives in Small-Diameter Vascular Graft Engineering
title_sort future perspectives in small-diameter vascular graft engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763104/
https://www.ncbi.nlm.nih.gov/pubmed/33321830
http://dx.doi.org/10.3390/bioengineering7040160
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