Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis

SIMPLE SUMMARY: Chronic liver injury and inflammation leads to excessive deposition of extracellular matrix, known as liver fibrosis, and the distortion of the hepatic parenchyma. Liver fibrosis may progress to cirrhosis, a condition in which hepatic function is impaired and most cases of liver tumo...

Descripción completa

Detalles Bibliográficos
Autores principales: Claveria-Cabello, Alex, Colyn, Leticia, Uriarte, Iker, Latasa, Maria Ujue, Arechederra, Maria, Herranz, Jose M., Alvarez, Laura, Urman, Jesus M., Martinez-Chantar, Maria L., Banales, Jesus M., Sangro, Bruno, Rombouts, Krista, Oyarzabal, Julen, Marin, Jose J. G., Berasain, Carmen, Avila, Matias A., Fernandez-Barrena, Maite G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763137/
https://www.ncbi.nlm.nih.gov/pubmed/33322158
http://dx.doi.org/10.3390/cancers12123748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763137/
https://www.ncbi.nlm.nih.gov/pubmed/33322158
http://dx.doi.org/10.3390/cancers12123748

Ejemplares similares