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Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition

Ga-68-DOTATOC-PET/MRI can affect the planning target volume (PTV) definition of meningiomas before radiosurgery. A shorter tracer uptake time before image acquisition could allow the examination of more patients. The aim of this study was to investigate if shortening uptake time is possible without...

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Autores principales: Graef, Josefine, Senger, Carolin, Wetz, Christoph, Baur, Alexander D. J., Kluge, Anne K., Lukas, Mathias, Rogasch, Julian M. M., Walter-Rittel, Thula C., Kohnert, David, Makowski, Marcus, Acker, Güliz, Huang, Kai, Budach, Volker, Amthauer, Holger, Schatka, Imke, Furth, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763245/
https://www.ncbi.nlm.nih.gov/pubmed/33322125
http://dx.doi.org/10.3390/diagnostics10121084
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author Graef, Josefine
Senger, Carolin
Wetz, Christoph
Baur, Alexander D. J.
Kluge, Anne K.
Lukas, Mathias
Rogasch, Julian M. M.
Walter-Rittel, Thula C.
Kohnert, David
Makowski, Marcus
Acker, Güliz
Huang, Kai
Budach, Volker
Amthauer, Holger
Schatka, Imke
Furth, Christian
author_facet Graef, Josefine
Senger, Carolin
Wetz, Christoph
Baur, Alexander D. J.
Kluge, Anne K.
Lukas, Mathias
Rogasch, Julian M. M.
Walter-Rittel, Thula C.
Kohnert, David
Makowski, Marcus
Acker, Güliz
Huang, Kai
Budach, Volker
Amthauer, Holger
Schatka, Imke
Furth, Christian
author_sort Graef, Josefine
collection PubMed
description Ga-68-DOTATOC-PET/MRI can affect the planning target volume (PTV) definition of meningiomas before radiosurgery. A shorter tracer uptake time before image acquisition could allow the examination of more patients. The aim of this study was to investigate if shortening uptake time is possible without compromising diagnostic accuracy and PET volume. Fifteen patients (f = 12; mean age 52 years (34–80 years)) with meningiomas were prospectively examined with dynamic [68Ga]Ga-68-labeled [DOTA0-Phe1-Tyr3] octreotide (Ga-68-DOTATOC)-PET/MRI over 70 min before radiosurgery planning. Meningiomas were delineated manually in the PET dataset. PET volumes at each time point were compared to the reference standard 60 min post tracer injection (p.i.) using the Friedman test followed by a Wilcoxon signed-rank test and Bonferroni correction. In all patients, the earliest time point with 100% lesion detection compared to 60 min p.i. was identified. PET volumes did not change significantly from 15 min p.i. (p = 1.0) compared to 60 min p.i. The earliest time point with 100% lesion detection in all patients was 10 min p.i. In patients with meningiomas undergoing Ga-68-DOTATOC-PET, the tracer uptake time can safely be reduced to 15 min p.i. with comparable PET volume and 100% lesion detection compared to 60 min p.i.
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spelling pubmed-77632452020-12-27 Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition Graef, Josefine Senger, Carolin Wetz, Christoph Baur, Alexander D. J. Kluge, Anne K. Lukas, Mathias Rogasch, Julian M. M. Walter-Rittel, Thula C. Kohnert, David Makowski, Marcus Acker, Güliz Huang, Kai Budach, Volker Amthauer, Holger Schatka, Imke Furth, Christian Diagnostics (Basel) Article Ga-68-DOTATOC-PET/MRI can affect the planning target volume (PTV) definition of meningiomas before radiosurgery. A shorter tracer uptake time before image acquisition could allow the examination of more patients. The aim of this study was to investigate if shortening uptake time is possible without compromising diagnostic accuracy and PET volume. Fifteen patients (f = 12; mean age 52 years (34–80 years)) with meningiomas were prospectively examined with dynamic [68Ga]Ga-68-labeled [DOTA0-Phe1-Tyr3] octreotide (Ga-68-DOTATOC)-PET/MRI over 70 min before radiosurgery planning. Meningiomas were delineated manually in the PET dataset. PET volumes at each time point were compared to the reference standard 60 min post tracer injection (p.i.) using the Friedman test followed by a Wilcoxon signed-rank test and Bonferroni correction. In all patients, the earliest time point with 100% lesion detection compared to 60 min p.i. was identified. PET volumes did not change significantly from 15 min p.i. (p = 1.0) compared to 60 min p.i. The earliest time point with 100% lesion detection in all patients was 10 min p.i. In patients with meningiomas undergoing Ga-68-DOTATOC-PET, the tracer uptake time can safely be reduced to 15 min p.i. with comparable PET volume and 100% lesion detection compared to 60 min p.i. MDPI 2020-12-13 /pmc/articles/PMC7763245/ /pubmed/33322125 http://dx.doi.org/10.3390/diagnostics10121084 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Graef, Josefine
Senger, Carolin
Wetz, Christoph
Baur, Alexander D. J.
Kluge, Anne K.
Lukas, Mathias
Rogasch, Julian M. M.
Walter-Rittel, Thula C.
Kohnert, David
Makowski, Marcus
Acker, Güliz
Huang, Kai
Budach, Volker
Amthauer, Holger
Schatka, Imke
Furth, Christian
Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title_full Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title_fullStr Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title_full_unstemmed Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title_short Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
title_sort shortened tracer uptake time in ga-68-dotatoc-pet of meningiomas does not impair diagnostic accuracy and pet volume definition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763245/
https://www.ncbi.nlm.nih.gov/pubmed/33322125
http://dx.doi.org/10.3390/diagnostics10121084
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